Depressive disorders in adolescence, recurrence in early adulthood, and healthcare usage in mid-adulthood: A longitudinal cost-of-illness study

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Depressive disorders in adolescence, recurrence in early adulthood, and healthcare usage in mid-adulthood : A longitudinal cost-of-illness study

Ssegonja, Richard (author): Uppsala universitet,Socialmedicin/CHAP,Department of Public Health and Caring Sciences, Child Health and Parenting (CHAP), Uppsala University, Uppsala, Sweden

Alaie, Iman (author): Uppsala universitet,Barn- och ungdomspsykiatri,Department of Neuroscience, Child and Adolescent Psychiatry, Uppsala University, Uppsala, Sweden

Philipson, Anna, 1978- (author): Örebro universitet,Institutionen för hälsovetenskaper,University Health Care Research Centre,Orebro Univ, Univ Hlth Care Res Ctr, Fac Med & Hlth, Orebro, Sweden

Hagberg, Lars, 1956- (author): Örebro universitet,Institutionen för hälsovetenskaper,Region Örebro län,University Health Care Research Centre,Orebro Univ, Univ Hlth Care Res Ctr, Fac Med & Hlth, Orebro, Sweden

Sampaio, Filipa, PhD, 1985- (author): Uppsala universitet,Socialmedicin/CHAP,Department of Public Health and Caring Sciences, Child Health and Parenting (CHAP), Uppsala University, Uppsala, Sweden

Möller, Margareta, 1951- (author): Örebro universitet,Institutionen för hälsovetenskaper,University Health Care Research Centre,Orebro Univ, Univ Hlth Care Res Ctr, Fac Med & Hlth, Orebro, Sweden

von Knorring, Lars (author): Uppsala universitet,Ekselius: Psykiatri,Department of Neuroscience, Psychiatry, Uppsala University, Uppsala, Sweden

Sarkadi, Anna, Professor, 1974- (author): Uppsala universitet,Socialmedicin/CHAP,Murdoch Childrens Res Inst, Melbourne, Vic, Australia,Department of Public Health and Caring Sciences, Child Health and Parenting (CHAP), Uppsala University, Uppsala, Sweden; Murdoch Children's Research Institute, Melbourne, Australia

Langenskiöld, Sophie, 1968- (author): Uppsala universitet,Kardiologi,Karolinska Inst, Dept Learning Informat Management & Eth LIME, Stockholm, Sweden,Department of Learning, Informatics, Management and Ethics (LIME), Karolinska Institutet, Sweden; Department of Medical Sciences, Uppsala University, Uppsala, Sweden

von Knorring, Anne-Liis, 1945- (author): Uppsala universitet,Barn- och ungdomspsykiatri,Department of Neuroscience, Child and Adolescent Psychiatry, Uppsala University, Uppsala, Sweden

Bohman, Hannes, 1965- (author): Karolinska Institutet,Uppsala universitet,Barn- och ungdomspsykiatri,Department of Neuroscience, Child and Adolescent Psychiatry, Uppsala University, Uppsala, Sweden

Jonsson, Ulf, 1974- (author): Karolinska Institutet,Uppsala universitet,Barn- och ungdomspsykiatri,Karolinska Inst Kind, Ctr Neurodev Disorders, Pediat Neuropsychiat Unit, Stockholm, Sweden;Stockholm Cty Council, Ctr Psychiat Res, Stockholm Hlth Care Serv, Stockholm, Sweden,Department of Neuroscience, Child and Adolescent Psychiatry, Uppsala University, Uppsala, Sweden; Center of Neurodevelopmental Disorders at Karolinska Institutet (KIND), Pediatric Neuropsychiatry Unit, Sweden; Centre for Psychiatry Research, Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden

Feldman, Inna, Docent, 1951- (author): Uppsala universitet,Socialmedicin/CHAP,Department of Public Health and Caring Sciences, Child Health and Parenting (CHAP), Uppsala University, Uppsala, Sweden

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ELSEVIER, 2019
2019
English.
In: Journal of Affective Disorders. - : ELSEVIER. - 0165-0327 .- 1573-2517. ; 258, s. 33-41

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; https://urn.kb.se/re...; http://kipublication...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Background: Depression in adolescence is associated with increased healthcare consumption in adulthood, but prior research has not recognized the heterogeneity of depressive disorders. This paper investigated the additional healthcare usage and related costs in mid-adulthood for individuals with adolescent depression, and examined the mediating role of subsequent depression in early adulthood.Methods: This study was based on the Uppsala Longitudinal Adolescent Depression Study, initiated in Sweden in the early 1990s. Depressive disorders were assessed in adolescence (age 16-17) and early adulthood (age 19-30). Healthcare usage and related costs in mid-adulthood (age 31-40) were estimated using nationwide population-based registries. Participants with specific subtypes of adolescent depression (n = 306) were compared with matched non-depressed peers (n = 213).Results: Women with persistent depressive disorder (PDD) in adolescence utilized significantly more healthcare resources in mid-adulthood. The association was not limited to psychiatric care, and remained after adjustment for individual and parental characteristics. The total additional annual cost for a single age group of females with a history of PDD at a population level was estimated at 3.10 million USD. Depression recurrence in early adulthood mediated the added costs for psychiatric care, but not for somatic care.Limitations: Primary health care data were not available, presumably resulting in an underestimation of the true healthcare consumption. Estimates for males had limited precision due to a relatively small male proportion.Conclusions: On a population level, the additional healthcare costs incurred in mid-adulthood in females with a history of adolescent PDD are considerable. Early treatment and prevention should be prioritized.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

Keyword

Adolescence
Depression
Direct costs
Adulthood
Psychiatric healthcare
Non-psychiatric healthcare

Publication and Content Type

ref (subject category)
art (subject category)

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Public Health Gl ...

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By the university: Uppsala University; Örebro University; Karolinska Institutet

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