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  • Boyd, Ben J.Monash Univ, Monash Inst Pharmaceut Sci, Drug Delivery Disposit & Dynam, Parkville, Vic, Australia (author)

Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • ELSEVIER,2019
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-393721
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-393721URI
  • https://doi.org/10.1016/j.ejps.2019.104967DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Poorly water-soluble drugs continue to be a problematic, yet important class of pharmaceutical compounds for treatment of a wide range of diseases. Their prevalence in discovery is still high, and their development is usually limited by our lack of a complete understanding of how the complex chemical, physiological and biochemical processes that occur between administration and absorption individually and together impact on bioavailability. This review defines the challenge presented by these drugs, outlines contemporary strategies to solve this challenge, and consequent in silico and in vitro evaluation of the delivery technologies for poorly water-soluble drugs. The next steps and unmet needs are proposed to present a roadmap for future studies for the field to consider enabling progress in delivery of poorly water-soluble compounds.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Bergström, Christel,1973-Uppsala universitet,Institutionen för farmaci(Swepub:uu)cjo29958 (author)
  • Vinarov, ZahariUniv Sofia, Fac Chem & Pharm, Sofia, Bulgaria (author)
  • Kuentz, MartinUniv Appl Sci & Arts Northwestern Switzerland, Inst Pharma Technol, Basel, Switzerland (author)
  • Brouwers, JoachimUniv Leuven, Drug Delivery & Disposit, Leuven, Belgium (author)
  • Augustijns, PatrickUniv Leuven, Drug Delivery & Disposit, Leuven, Belgium (author)
  • Brandl, MartinUniv Southern Denmark, Dept Phys Chem & Pharm, Odense, Denmark (author)
  • Bernkop-Schnürch, AndreasUniv Innsbruck, Inst Pharm, Dept Pharmaceut Technol, Innsbruck, Austria (author)
  • Shrestha, NehaCatholic Univ Louvain, Louvain Drug Res Inst, Adv Drug Delivery & Biomat, Brussels, Belgium (author)
  • Preat, VeroniqueCatholic Univ Louvain, Louvain Drug Res Inst, Adv Drug Delivery & Biomat, Brussels, Belgium (author)
  • Müllertz, AnetteUniv Copenhagen, Physiol Pharmaceut, Copenhagen, Denmark (author)
  • Bauer-Brandl, AnnetteUniv Southern Denmark, Dept Phys Chem & Pharm, Odense, Denmark (author)
  • Jannin, VincentGattefosse SAS, St Priest, France (author)
  • Monash Univ, Monash Inst Pharmaceut Sci, Drug Delivery Disposit & Dynam, Parkville, Vic, AustraliaInstitutionen för farmaci (creator_code:org_t)

Related titles

  • In:European Journal of Pharmaceutical Sciences: ELSEVIER1370928-09871879-0720

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