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Modulation of p53 a...
Modulation of p53 and prion protein aggregation by RNA
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- Cordeiro, Yraima (author)
- Univ Fed Rio de Janeiro, Fac Pharm, BR-21941902 Rio De Janeiro, Brazil
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- Vieira, Tuane (author)
- Univ Fed Rio de Janeiro, Inst Bioquim Med Leopoldo Meis, Inst Nacl Ciencia Tecnol Biol Estrutural & Bioima, BR-21941902 Rio De Janeiro, Brazil
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- Kovachev, Petar Stefanov (author)
- Uppsala universitet,Molekylärbiologi
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- Sanyal, Suparna (author)
- Uppsala universitet,Molekylärbiologi
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- Silva, Jerson L. (author)
- Univ Fed Rio de Janeiro, Inst Bioquim Med Leopoldo Meis, Inst Nacl Ciencia Tecnol Biol Estrutural & Bioima, BR-21941902 Rio De Janeiro, Brazil
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(creator_code:org_t)
- Elsevier BV, 2019
- 2019
- English.
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In: Biochimica et Biophysica Acta - Proteins and Proteomics. - : Elsevier BV. - 1570-9639 .- 1878-1454. ; 1867:10, s. 933-940
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Several RNA-binding proteins undergo reversible liquid-liquid phase transitions, which, in pathological conditions, might evolve into transitions to solid-state phases, giving rise to amyloid structures. Amyloidogenic and prion-like proteins, such as the tumor suppressor protein p53 and the mammalian prion protein (PrP), bind RNAs specifically or nonspecifically, resulting in changes in their propensity to undergo aggregation. Mutant p53 aggregation seems to play a crucial role in cancer through loss of function, negative dominance and gain of function. PrP conversion modulated by RNA results in highly toxic aggregates. Here, we review data on the modulatory action of RNAs on the aggregation of both proteins.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
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