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Increased mast cell...
Increased mast cell degranulation and co-localization of mast cells with the NMDA receptor-1 during healing after Achilles tendon rupture
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- Alim, Md Abdul (author)
- Uppsala universitet,Allmänmedicin och preventivmedicin,Department of Molecular Medicine and Surgery, Karolinska Institutet,Uppsala University, Sweden; Karolinska Institute, Sweden; Uppsala University, Sweden
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- Ackermann, Paul W (author)
- Karolinska Institutet,Karolinska Institute, Sweden; Karolinska University Hospital, Sweden
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- Eliasson, Pernilla, 1982- (author)
- Linköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten
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- Blomgran, Parmis (author)
- Linköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten
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- Kristiansson, Per (author)
- Uppsala universitet,Allmänmedicin och preventivmedicin,Uppsala University, Sweden
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- Pejler, Gunnar (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Swedish Univ Agr Sci, Dept Anat Physiol & Biochem, Uppsala, Sweden,Uppsala University, Sweden; Swedish University of Agriculture Science, Sweden,Institutionen för anatomi, fysiologi och biokemi,Department of Anatomy, Physiology and Biochemistry (AFB)
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- Peterson, Magnus, 1966- (author)
- Uppsala universitet,Allmänmedicin och preventivmedicin,Uppsala University, Sweden
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(creator_code:org_t)
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- 2017-10-03
- 2017
- English.
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In: Cell and Tissue Research. - Berlin Heidelberg : Springer Science and Business Media LLC. - 0302-766X .- 1432-0878. ; 370:3, s. 451-460
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Abstract
Subject headings
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- The role of inflammation and the mechanism of tendon healing after rupture has historically been a matter of controversy. The purpose of the present study is to investigate the role of mast cells and their relation to the NMDA receptor-1 (a glutamate receptor) during healing after Achilles tendon rupture. Eight female Sprague Dawley rats had their right Achilles tendon transected. Three weeks after rupture, histological quantification of mast cell numbers and their state of degranulation was assessed by histochemistry. Co-localization of mast cell tryptase (a mast cell marker) and NMDA receptor-1 was determined by immunofluorescence. The intact left Achilles tendon was used as control. An increased number of mast cells and a higher proportion of degranulated mast cells were found in the healing Achilles tendon compared to the intact. In addition, increased co-localization of mast cell tryptase and NMDA receptor-1 was seen in the areas of myotendinous junction, mid-tendon proper and bone tendon junction of the healing versus the intact tendon. These findings introduce a possible role for mast cells in the healing phase after Achilles tendon rupture.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- Achilles tendon healing
- Mast cells
- NMDA
- Rats
- Tryptase
- Orthopaedics
- Ortopedi
- Immunologi
- Immunology
Publication and Content Type
- ref (subject category)
- art (subject category)
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