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Novel Y-Chromosome ...
Novel Y-Chromosome Long Non-Coding RNAs Expressed in Human Male CNS During Early Development
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- Johansson, Martin M., 1976- (author)
- Uppsala universitet,Evolution och utvecklingsbiologi
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- Pottmeier, Philipp (author)
- Uppsala universitet,Evolution och utvecklingsbiologi
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- Suciu, Pascalina (author)
- Uppsala universitet,Evolution och utvecklingsbiologi
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- Ahmed, Tauseef (author)
- Uppsala universitet,Evolution och utvecklingsbiologi
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- Zaghlool, Ammar, 1980- (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik
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- Halvardson, Jonatan, 1982- (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik
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- Darj, Elisabeth, 1953- (author)
- Uppsala universitet,Internationell mödra- och barnhälsovård (IMCH),Norwegian Univ Sci & Technol, Dept Publ Hlth & Gen Practice, Trondheim, Norway
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- Feuk, Lars (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik
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- Peuckert, Christiane (author)
- Uppsala universitet,Evolution och utvecklingsbiologi,Stockholms Univ, Dept Mol Biol, Stockholm, Sweden
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- Jazin, Elena (author)
- Uppsala universitet,Evolution och utvecklingsbiologi
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(creator_code:org_t)
- 2019-09-24
- 2019
- English.
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In: Frontiers in Genetics. - : Frontiers Media S.A.. - 1664-8021. ; 10
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Abstract
Subject headings
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- Global microarray gene expression analyses previously demonstrated differences in female and male embryos during neurodevelopment. In particular, before sexual maturation of the gonads, the differences seem to concentrate on the expression of genes encoded on the X- and Y-chromosomes. To investigate genome-wide differences in expression during this early developmental window, we combined high-resolution RNA sequencing with qPCR to analyze brain samples from human embryos during the first trimester of development. Our analysis was tailored for maximum sensitivity to discover Y-chromosome gene expression, but at the same time, it was underpowered to detect X-inactivation escapees. Using this approach, we found that 5 out of 13 expressed gametolog pairs showed unbalanced gene dosage, and as a consequence, a male-biased expression. In addition, we found six novel non-annotated long non-coding RNAs on the Y-chromosome with conserved expression patterns in newborn chimpanzee. The tissue specific and time-restricted expression of these long non-coding RNAs strongly suggests important functions during central nervous system development in human males.
Subject headings
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- sex differences
- gene expression
- X-chromosome
- Y-chromosome
- long non-coding RNA
- RNA sequencing
- human brain development
- Pan troglodytes
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Johansson, Marti ...
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Pottmeier, Phili ...
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Suciu, Pascalina
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Ahmed, Tauseef
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Zaghlool, Ammar, ...
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Halvardson, Jona ...
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show more...
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Darj, Elisabeth, ...
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Feuk, Lars
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Peuckert, Christ ...
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Jazin, Elena
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Frontiers in Gen ...
- By the university
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Uppsala University