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Protective effects ...
Protective effects of Clec11a in islets against lipotoxicity via modulation of proliferation and lipid metabolism in mice
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- Shi, Ruifeng (author)
- Southeast Univ, Sch Med, Inst Diabet, Dept Endocrinol,Zhongda Hosp, Nanjing 210009, Jiangsu, Peoples R China;Southeast Univ, Sch Med, Nanjing 210009, Jiangsu, Peoples R China
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- Hu, Juan (author)
- Southeast Univ, Sch Med, Dept Biochem & Mol Biol, Nanjing 210009, Jiangsu, Peoples R China
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- Li, Wei (author)
- Southeast Univ, Sch Med, Inst Diabet, Dept Endocrinol,Zhongda Hosp, Nanjing 210009, Jiangsu, Peoples R China
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- Wang, Zhirong (author)
- Southeast Univ, Sch Med, Dept Biochem & Mol Biol, Nanjing 210009, Jiangsu, Peoples R China
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- Pan, Ye (author)
- Southeast Univ, Sch Med, Dept Biochem & Mol Biol, Nanjing 210009, Jiangsu, Peoples R China
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- Bai, Mei (author)
- Southeast Univ, Sch Med, Dept Biochem & Mol Biol, Nanjing 210009, Jiangsu, Peoples R China
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- Mao, Wantong (author)
- Southeast Univ, Sch Med, Dept Biochem & Mol Biol, Nanjing 210009, Jiangsu, Peoples R China
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- Wang, Xiaohang (author)
- Southeast Univ, Sch Med, Inst Diabet, Dept Endocrinol,Zhongda Hosp, Nanjing 210009, Jiangsu, Peoples R China
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- Zhong, Ming (author)
- Southeast Univ, Sch Med, Dept Biochem & Mol Biol, Nanjing 210009, Jiangsu, Peoples R China
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- Yuan, Yang (author)
- Southeast Univ, Sch Med, Inst Diabet, Dept Endocrinol,Zhongda Hosp, Nanjing 210009, Jiangsu, Peoples R China
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- Lau, Joey, 1979- (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Sun, Zilin (author)
- Southeast Univ, Sch Med, Inst Diabet, Dept Endocrinol,Zhongda Hosp, Nanjing 210009, Jiangsu, Peoples R China;Southeast Univ, Sch Med, Nanjing 210009, Jiangsu, Peoples R China
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- Zhao, Sheng (author)
- Southeast Univ, Sch Med, Dept Biochem & Mol Biol, Nanjing 210009, Jiangsu, Peoples R China
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(creator_code:org_t)
- ELSEVIER INC, 2019
- 2019
- English.
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In: Experimental Cell Research. - : ELSEVIER INC. - 0014-4827 .- 1090-2422. ; 384:1
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The lipotoxicity is considered as one of the risk for diabetes. Here we report C-type lectin domain family 11, member A (Clec11a) as a new regulator in islet playing a protective role in lipotoxicity induced dysfunction. Islet transcriptome sequencing was performed using the high-fat diet induced obesity (DIO) mice model. We found a significant decrease of Clec11a expression in islets of DIO mice compared to normal control mice, which was further confirmed by real-time PCR. Immunostaining demonstrated the localization of the Clec11a protein in mouse islets. Administration of recombinant human Clec11a (rClec11a) protein promoted the proliferation of islet cells and rescued the inhibition of fatty acid on cell proliferation, which involved the activation of Erk signaling pathway. We also found that the rClec11a altered the expression of genes involved in lipid metabolism.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- Clec11a
- Beta cell
- Islet
- Lipotoxicity
- Proliferation
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Shi, Ruifeng
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Hu, Juan
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Li, Wei
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Wang, Zhirong
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Pan, Ye
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Bai, Mei
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show more...
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Mao, Wantong
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Wang, Xiaohang
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Zhong, Ming
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Yuan, Yang
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Lau, Joey, 1979-
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Sun, Zilin
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Zhao, Sheng
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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Experimental Cel ...
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Uppsala University