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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005427naa a2200505 4500
001oai:DiVA.org:uu-396434
003SwePub
008191106s2019 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3964342 URI
0247 a https://doi.org/10.1128/JVI.01150-192 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Henry, Caroleu Univ Chicago, Dept Med, Sect Rheumatol, 5841 S Maryland Ave, Chicago, IL 60637 USA4 aut
2451 0a Monoclonal Antibody Responses after Recombinant Hemagglutinin Vaccine versus Subunit Inactivated Influenza Virus Vaccine :b a Comparative Study
264 1b AMER SOC MICROBIOLOGY,c 2019
338 a print2 rdacarrier
520 a Vaccination is the best measure of protection against influenza virus infection. Vaccine-induced antibody responses target mainly the hemagglutinin (HA) surface glycoprotein, composed of the head and the stalk domains. Recently two novel vaccine platforms have been developed for seasonal influenza vaccination: a recombinant HA vaccine produced in insect cells (Flublok) and Flucelvax, prepared from virions produced in mammalian cells. In order to compare the fine specificity of the antibodies induced by these two novel vaccine platforms, we characterized 42 Flublok-induced monoclonal antibodies (MAbs) and 38 Flucelvax-induced MAbs for avidity, cross-reactivity, and any selectivity toward the head versus the stalk domain. These studies revealed that Flublok induced a greater proportion of MAbs targeting epitopes near the receptor-binding domain on HA head (hemagglutinin inhibition-positive MAbs) than Flucelvax, while the two vaccines induced similar low frequencies of stalk-reactive MAbs. Finally, mice immunized with Flublok and Flucelvax also induced similar frequencies of stalk-reactive antibody-secreting cells, showing that HA head immunodominance is independent of immune memory bias. Collectively, our results suggest that these vaccine formulations are similarly immunogenic but differ in the preferences of the elicited antibodies toward the receptor-binding domain on the HA head.IMPORTANCE: There are ongoing efforts to increase the efficacy of influenza vaccines and to promote production strategies that can rapidly respond to newly emerging viruses. It is important to understand if current alternative seasonal vaccines, such as Flublok and Flucelvax, that use alternate production strategies can induce protective influenza-specific antibodies and to evaluate what type of epitopes are targeted by distinct vaccine formulations.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng
653 a Flublok
653 a Flucelvax
653 a antibody responses
653 a influenza vaccines
7001 a Palm, Anna-Karin E.,d 1983-u Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Univ Chicago, Dept Med, Sect Rheumatol, 5841 S Maryland Ave, Chicago, IL 60637 USA4 aut0 (Swepub:uu)annpa506
7001 a Utset, Henry A.u Univ Chicago, Dept Med, Sect Rheumatol, 5841 S Maryland Ave, Chicago, IL 60637 USA4 aut
7001 a Huang, Minu Univ Chicago, Dept Med, Sect Rheumatol, 5841 S Maryland Ave, Chicago, IL 60637 USA4 aut
7001 a Ho, Irvin Y.u Univ Chicago, Dept Med, Sect Rheumatol, 5841 S Maryland Ave, Chicago, IL 60637 USA4 aut
7001 a Zheng, Nai-Yingu Univ Chicago, Dept Med, Sect Rheumatol, 5841 S Maryland Ave, Chicago, IL 60637 USA4 aut
7001 a Fitzgerald, Theresau Univ Rochester, Med Ctr, Dept Microbiol & Immunol, Ctr Vaccine Biol & Immunol, Rochester, NY 14642 USA4 aut
7001 a Neu, Karlynn E.u Univ Chicago, Dept Med, Sect Rheumatol, 5841 S Maryland Ave, Chicago, IL 60637 USA4 aut
7001 a Chen, Yao-Qingu Univ Chicago, Dept Med, Sect Rheumatol, 5841 S Maryland Ave, Chicago, IL 60637 USA4 aut
7001 a Krammer, Florianu Icahn Sch Med Mt Sinai, Dept Microbiol, New York, NY 10029 USA4 aut
7001 a Treanor, John J.u Univ Rochester, Med Ctr, Dept Med, Div Infect Dis, Rochester, NY 14642 USA4 aut
7001 a Sant, Andrea J.u Univ Rochester, Med Ctr, Dept Microbiol & Immunol, Ctr Vaccine Biol & Immunol, Rochester, NY 14642 USA4 aut
7001 a Topham, David J.u Univ Rochester, Med Ctr, Dept Microbiol & Immunol, Ctr Vaccine Biol & Immunol, Rochester, NY 14642 USA4 aut
7001 a Wilson, Patrick C.u Univ Chicago, Dept Med, Sect Rheumatol, 5841 S Maryland Ave, Chicago, IL 60637 USA4 aut
7102 a Univ Chicago, Dept Med, Sect Rheumatol, 5841 S Maryland Ave, Chicago, IL 60637 USAb Institutionen för medicinsk biokemi och mikrobiologi4 org
7730 t Journal of Virologyd : AMER SOC MICROBIOLOGYg 93:21q 93:21x 0022-538Xx 1098-5514
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-396434
8564 8u https://doi.org/10.1128/JVI.01150-19

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