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Lowered anti-beta1 ...
Lowered anti-beta1 adrenergic receptor antibody concentrations may have prognostic significance in acute coronary syndrome
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- Ernst, Diana (author)
- Med Sch Hannover, Dept Immunol & Rheumatol, Hannover, Germany
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- Westerbergh, Johan (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)
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- Sogkas, Georgios (author)
- Med Sch Hannover, Dept Immunol & Rheumatol, Hannover, Germany
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- Jablonka, Alexandra (author)
- Med Sch Hannover, Dept Immunol & Rheumatol, Hannover, Germany
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- Ahrenstorf, Gerrit (author)
- Med Sch Hannover, Dept Immunol & Rheumatol, Hannover, Germany
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- Schmidt, Reinhold Ernst (author)
- Med Sch Hannover, Dept Immunol & Rheumatol, Hannover, Germany
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- Heidecke, Harald (author)
- CellTrend GmbH, Luckenwalde, Germany
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- Wallentin, Lars, 1943- (author)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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- Riemekasten, Gabriela (author)
- Univ Schleswig Holstein, Dept Rheumatol, Lubeck, Germany
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- Witte, Torsten (author)
- Med Sch Hannover, Dept Immunol & Rheumatol, Hannover, Germany
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(creator_code:org_t)
- 2019-10-10
- 2019
- English.
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In: Scientific Reports. - : NATURE PUBLISHING GROUP. - 2045-2322. ; 9
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Abstract
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- Although several risk factors exist for acute coronary syndrome (ACS) no biomarkers for survival or risk of re-infarction have been validated. Previously, reduced serum concentrations of anti-beta(1)AR Ab have been implicated in poorer ACS outcomes. This study further evaluates the prognostic implications of anti-beta(1)AR-Ab levels at the time of ACS onset. Serum anti-beta(1)AR Ab concentrations were measured in randomly selected patients from within the PLATO cohort. Stratification was performed according to ACS event: ST-elevation myocardial infarct (STEMI) vs. non-ST elevation myocardial infarct (NSTEMI). Antibody concentrations at ACS presentation were compared to 12-month all-cause and cardiovascular mortality, as well as 12-month re-infarction. Sub-analysis, stratifying for age and the correlation between antibody concentration and conventional cardiac risk-factors was subsequently performed. Serum anti-beta(1)AR Ab concentrations were measured in 400/799 (50%) STEMI patients and 399 NSTEMI patients. Increasing anti-beta(1)AR Ab concentrations were associated with STEMI (p = 0.001). Across all ACS patients, no associations between anti-beta(1)AR Ab concentration and either all-cause cardiovascular death or myocardial re-infarction (p = 0.14) were evident. However among STEMI patients <60 years with anti-beta(1)AR Ab concentration median (14/198 (7.1%) vs. 2/190 (1.1%)); p = 0.01). Similarly, the same sub-group demonstrated greater risk of cardiovascular death in year 1, including re-infarction and stroke (22/198 (11.1%) vs. 10/190 (5.3%); p = 0.017). ACS Patients <= 60 years, exhibiting lower concentrations of beta(1)AR Ab carry a greater risk for early re-infarction and cardiovascular death. Large, prospective studies quantitatively assessing the prognostic relevance of Anti-beta(1)AR Ab levels should be considered.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Ernst, Diana
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Westerbergh, Joh ...
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Sogkas, Georgios
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Jablonka, Alexan ...
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Ahrenstorf, Gerr ...
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Schmidt, Reinhol ...
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Heidecke, Harald
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Wallentin, Lars, ...
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Riemekasten, Gab ...
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Witte, Torsten
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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Scientific Repor ...
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Uppsala University