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Circulating Vitamin...
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Larsson, Susanna C.Karolinska Institutet,Uppsala universitet,Ortopedi
(author)
Circulating Vitamin K₁ Levels in Relation to Ischemic Stroke and Its Subtypes : A Mendelian Randomization Study.
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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2018-10-25
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MDPI AG,2018
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electronicrdacarrier
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LIBRIS-ID:oai:DiVA.org:uu-397238
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-397238URI
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https://doi.org/10.3390/nu10111575DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:139708001URI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Vitamin K plays a crucial role in blood coagulation, and hypercoagulability has been linked to atherosclerosis-related vascular disease. We used the Mendelian randomization study design to examine whether circulating vitamin K₁ (phylloquinone) levels are associated with ischemic stroke. Four single-nucleotide polymorphisms associated with vitamin K₁ levels were used as instrumental variables. Summary-level data for large artery atherosclerotic stroke (n = 4373 cases), small vessel stroke (n = 5386 cases), cardioembolic stroke (n = 7193 cases), and any ischemic stroke (n = 34,217 cases and 404,630 non-cases) were available from the MEGASTROKE consortium. Genetically-predicted circulating vitamin K₁ levels were associated with large artery atherosclerotic stroke but not with any other subtypes or ischemic stroke as a whole. The odds ratios per genetically predicted one nmol/L increase in natural log-transformed vitamin K₁ levels were 1.31 (95% confidence interval (CI) 1.12⁻1.53; p = 7.0 × 10-4) for large artery atherosclerotic stroke, 0.98 (95% CI 0.85⁻1.12; p = 0.73) for small vessel stroke, 1.01 (95% CI 0.90⁻1.14; p = 0.84) for cardioembolic stroke, and 1.05 (95% CI 0.99⁻1.11; p = 0.11) for any ischemic stroke. These findings indicate that genetic predisposition to higher circulating vitamin K₁ levels is associated with an increased risk of large artery atherosclerotic stroke.
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Traylor, Matthew
(author)
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Markus, Hugh S
(author)
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Uppsala universitetOrtopedi
(creator_code:org_t)
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In:Nutrients: MDPI AG10:112072-6643
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