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Detection of a High-Turnover Serotonin Circuit in the Mouse Brain Using Mass Spectrometry Imaging

Sugiyama, Eiji (author)
Keio Univ, Dept Biochem, Sch Med, Shinjuku Ku, 35 Shinanomachi, Tokyo 1608582, Japan
Guerrini, Matteo M. (author)
RIKEN Yokohama Inst, Ctr Integrat Med Sci, Lab Mucosal Immun, Suehirocho,1 Chome 7-22, Yokohama, Kanagawa 2300045, Japan
Honda, Kurara (author)
Keio Univ, Dept Biochem, Sch Med, Shinjuku Ku, 35 Shinanomachi, Tokyo 1608582, Japan
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Hattori, Yuko (author)
Keio Univ, Dept Biochem, Sch Med, Shinjuku Ku, 35 Shinanomachi, Tokyo 1608582, Japan
Abe, Manabu (author)
Niigata Univ, Brain Res Inst, Dept Anim Model Dev, Chuo Ku, 1-757 Asahimachi Dori, Niigata 9518585, Japan
Källback, Patrik (author)
Uppsala universitet,Institutionen för farmaceutisk biovetenskap
Andrén, Per E. (author)
Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Science for Life Laboratory, SciLifeLab,Uppsala Univ, Med Mass Spectrometry Imaging, Box 591 BMC, S-75124 Uppsala, Sweden;Uppsala Univ, Sci Life Lab, Natl Resource Mass Spectrometry Imaging, Box 591 BMC, S-75124 Uppsala, Sweden
Tanaka, Kenji F. (author)
Keio Univ, Dept Neuropsychiat, Sch Med, Shinjuku Ku, 35 Shinanomachi, Tokyo 1608582, Japan
Setou, Mitsutoshi (author)
Hamamatsu Univ Sch Med, Dept Cellular & Mol Anat, Higashi Ku, 1-20-1 Handayama, Hamamatsu, Shizuoka 4313192, Japan;Hamamatsu Univ Sch Med, Int Mass Imaging Ctr, Higashi Ku, 1-20-1 Handayama, Hamamatsu, Shizuoka 4313192, Japan
Fagarasani, Sidonia (author)
RIKEN Yokohama Inst, Ctr Integrat Med Sci, Lab Mucosal Immun, Suehirocho,1 Chome 7-22, Yokohama, Kanagawa 2300045, Japan
Suematsu, Makoto (author)
Keio Univ, Dept Biochem, Sch Med, Shinjuku Ku, 35 Shinanomachi, Tokyo 1608582, Japan
Sugiura, Yuki (author)
Keio Univ, Dept Biochem, Sch Med, Shinjuku Ku, 35 Shinanomachi, Tokyo 1608582, Japan
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 (creator_code:org_t)
CELL PRESS, 2019
2019
English.
In: iScience. - : CELL PRESS. - 2589-0042. ; 20, s. 359-
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Monoamine neurotransmitters are released by specialized neurons regulating behavioral, motor, and cognitive functions. Although the localization of monoaminergic neurons in the brain is well known, the distribution and kinetics of monoamines remain unclear. Here, we generated a murine brain atlas of serotonin (5-HT), dopamine (DA), and norepinephrine (NE) levels using mass spectrometry imaging (MSI). We found several nuclei rich in both 5-HT and a catecholamine (DA or NE) and identified the paraventricular nucleus of the thalamus (PVT), where 5-HT and NE are co-localized. The analysis of 5-HT fluctuations in response to acute tryptophan depletion and infusion of isotope-labeled tryptophan in vivo revealed a close kinetic association between the raphe nuclei, PVT, and amygdala but not the other nuclei. Our findings imply the existence of a highly dynamic 5-HT-mediated raphe to PVT pathway that likely plays a role in the brain monoamine system.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)

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