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R3hdml regulates satellite cell proliferation and differentiation

Sakamoto, Kenichi (author)
Chiba Univ, Grad Sch Med, Dept Endocrinol Hematol & Gerontol, Chiba, Japan
Furuichi, Yasuro (author)
Tokyo Metropolitan Univ, Grad Sch Human Hlth Sci, Dept Hlth Promot Sci, Hachioji, Tokyo, Japan
Yamamoto, Masashi (author)
Chiba Univ, Grad Sch Med, Dept Endocrinol Hematol & Gerontol, Chiba, Japan
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Takahashi, Megumi (author)
Tokyo Metropolitan Univ, Grad Sch Human Hlth Sci, Dept Hlth Promot Sci, Hachioji, Tokyo, Japan
Akimoto, Yoshihiro (author)
Kyorin Univ, Sch Med, Dept Anat, Tokyo, Japan
Ishikawa, Takahiro (author)
Chiba Univ, Grad Sch Med, Dept Endocrinol Hematol & Gerontol, Chiba, Japan;Chiba Univ Hosp, Div Diabet Metab & Endocrinol, Chiba, Japan
Shimizu, Takahiko (author)
Chiba Univ, Grad Sch Med, Dept Endocrinol Hematol & Gerontol, Chiba, Japan;Natl Ctr Geriatr & Gerontol, Aging Stress Response Res Project Team, Obu, Aichi, Japan
Fujimoto, Masanori (author)
Chiba Univ, Grad Sch Med, Dept Endocrinol Hematol & Gerontol, Chiba, Japan
Takada-Watanabe, Aki (author)
Chiba Univ, Grad Sch Med, Dept Endocrinol Hematol & Gerontol, Chiba, Japan
Hayashi, Aiko (author)
Chiba Univ, Grad Sch Med, Dept Endocrinol Hematol & Gerontol, Chiba, Japan
Mita, Yoshitaka (author)
Tokyo Metropolitan Univ, Grad Sch Human Hlth Sci, Dept Hlth Promot Sci, Hachioji, Tokyo, Japan
Manabe, Yasuko (author)
Tokyo Metropolitan Univ, Grad Sch Human Hlth Sci, Dept Hlth Promot Sci, Hachioji, Tokyo, Japan
Fujii, Nobuharu L. (author)
Tokyo Metropolitan Univ, Grad Sch Human Hlth Sci, Dept Hlth Promot Sci, Hachioji, Tokyo, Japan
Ishibashi, Ryoichi (author)
Chiba Univ, Grad Sch Med, Dept Endocrinol Hematol & Gerontol, Chiba, Japan
Maezawa, Yoshiro (author)
Chiba Univ, Grad Sch Med, Dept Endocrinol Hematol & Gerontol, Chiba, Japan;Chiba Univ Hosp, Div Diabet Metab & Endocrinol, Chiba, Japan
Betsholtz, Christer (author)
Uppsala universitet,Vaskulärbiologi,Karolinska Inst, Novum, ICMC, Huddinge, Sweden
Yokote, Koutaro (author)
Chiba Univ, Grad Sch Med, Dept Endocrinol Hematol & Gerontol, Chiba, Japan;Chiba Univ Hosp, Div Diabet Metab & Endocrinol, Chiba, Japan
Takemoto, Minoru (author)
Chiba Univ, Grad Sch Med, Dept Endocrinol Hematol & Gerontol, Chiba, Japan;Int Univ Hlth & Welf, Dept Diabet Metab & Endocrinol, Sch Med, Chiba, Japan
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 (creator_code:org_t)
2019-09-16
2019
English.
In: EMBO Reports. - : John Wiley & Sons. - 1469-221X .- 1469-3178. ; 20:11
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • In this study, we identified a previously uncharacterized skeletal satellite cell-secreted protein, R3h domain containing-like (R3hdml). Expression of R3hdml increases during skeletal muscle development and differentiation in mice. Body weight and skeletal muscle mass of R3hdml knockout (KO) mice are lower compared to control mice. Expression levels of cell cycle-related markers, phosphorylation of Akt, and expression of insulin-like growth factor within the skeletal muscle are reduced in R3hdml KO mice compared to control mice. Expression of R3hdml increases during muscle regeneration in response to cardiotoxin (CTX)-induced muscle injury. Recovery of handgrip strength after CTX injection was significantly impaired in R3hdml KO mice, which is rescued by R3hdml. Our results indicate that R3hdml is required for skeletal muscle development, regeneration, and, in particular, satellite cell proliferation and differentiation.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

Keyword

R3hdml
sarcopenia
satellite cell
skeletal muscle

Publication and Content Type

ref (subject category)
art (subject category)

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