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Predicting Developm...
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Luikku, Antti J.Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland;Univ Eastern Finland, Inst Clin Med Neurosurg, Kuopio, Finland;Kuopio Univ Hosp, NeuroCtr, Neurosurg, POB 100, FIN-70029 Kuopio, Finland
(author)
Predicting Development of Alzheimer's Disease in Patients with Shunted Idiopathic Normal Pressure Hydrocephalus
- Article/chapterEnglish2019
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LIBRIS-ID:oai:DiVA.org:uu-398155
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-398155URI
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https://doi.org/10.3233/JAD-190334DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:142085613URI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Background: Idiopathic normal pressure hydrocephalus (iNPH) patients often develop Alzheimer's disease (AD) related brain pathology. Disease State Index (DSI) is a method to combine data from various sources for differential diagnosis and progression of neurodegenerative disorders.Objective: To apply DSI to predict clinical AD in shunted iNPH-patients in a defined population.Methods: 335 shunted iNPH-patients (median 74 years) were followed until death (n = 185) or 6/2015 (n = 150). DSI model (including symptom profile, onset age of NPH symptoms, atrophy of medial temporal lobe in CT/MRI, cortical brain biopsy finding, and APOE genotype) was applied. Performance of DSI model was evaluated with receiver operating characteristic (ROC) curve analysis.Results: A total of 70 (21%) patients developed clinical AD during median follow-up of 5.3 years. DSI-model predicted clinical AD with moderate effectiveness (AUC= 0.75). Significant factors were cortical biopsy (0.69), clinical symptoms (0.66), and medial temporal lobe atrophy (0.66).Conclusion: We found increased occurrence of clinical AD in previously shunted iNPH patients as compared with general population. DSI supported the prediction of AD. Cortical biopsy during shunt insertion seems indicated for earlier diagnosis of comorbid AD.
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Hall, AnetteUniv Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland
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Nerg, OssiUniv Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland;Kuopio Univ Hosp, NeuroCtr, Neurol, Kuopio, Finland
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Koivisto, Anne M.Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland;Kuopio Univ Hosp, NeuroCtr, Neurol, Kuopio, Finland
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Hiltunen, MikkoUniv Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland;Kuopio Univ Hosp, NeuroCtr, Neurol, Kuopio, Finland;Univ Eastern Finland, Inst Biomed, Kuopio, Finland
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Helisalmi, SeppoUniv Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland
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Herukka, Sanna-KaisaUniv Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland;Kuopio Univ Hosp, NeuroCtr, Neurol, Kuopio, Finland
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Junkkari, AnttiUniv Eastern Finland, Inst Clin Med Neurosurg, Kuopio, Finland;Kuopio Univ Hosp, NeuroCtr, Neurosurg, POB 100, FIN-70029 Kuopio, Finland
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Sutela, AnnaKuopio Univ Hosp, Dept Radiol, Kuopio, Finland
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Kojoukhova, MariaKuopio Univ Hosp, NeuroCtr, Neurosurg, POB 100, FIN-70029 Kuopio, Finland;Kuopio Univ Hosp, Dept Radiol, Kuopio, Finland
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Korhonen, VilleKuopio Univ Hosp, NeuroCtr, Neurosurg, POB 100, FIN-70029 Kuopio, Finland
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Mattila, JussiCombinostics Ltd, Tampere, Finland
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Lötjönen, JyrkiCombinostics Ltd, Tampere, Finland
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Rummukainen, JaanaKuopio Univ Hosp, Dept Pathol, Kuopio, Finland;Univ Eastern Finland, Dept Pathol, Kuopio, Finland
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Alafuzoff, IrinaUppsala universitet,Klinisk och experimentell patologi(Swepub:uu)irial548
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Jääskeläinen, Juha E.Univ Eastern Finland, Inst Clin Med Neurosurg, Kuopio, Finland;Kuopio Univ Hosp, NeuroCtr, Neurosurg, POB 100, FIN-70029 Kuopio, Finland
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Remes, Anne M.Univ Oulu, Res Unit Clin Neurosci, Neurol, Oulu, Finland;Oulu Univ Hosp, Med Res Ctr, Oulu, Finland
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Solomon, AlinaKarolinska Institutet
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Kivipelto, MiiaKarolinska Institutet
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Soininena, HilkkaUniv Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland;Kuopio Univ Hosp, NeuroCtr, Neurol, Kuopio, Finland
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Rauramaa, TuomasKuopio Univ Hosp, Dept Pathol, Kuopio, Finland;Univ Eastern Finland, Dept Pathol, Kuopio, Finland
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Leinonen, VilleUniv Eastern Finland, Inst Clin Med Neurosurg, Kuopio, Finland;Kuopio Univ Hosp, NeuroCtr, Neurosurg, POB 100, FIN-70029 Kuopio, Finland;Oulu Univ Hosp, Med Res Ctr, Oulu, Finland;Univ Oulu, Res Unit Clin Neurosci, Neurosurg, Oulu, Finland
(author)
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Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland;Univ Eastern Finland, Inst Clin Med Neurosurg, Kuopio, Finland;Kuopio Univ Hosp, NeuroCtr, Neurosurg, POB 100, FIN-70029 Kuopio, FinlandUniv Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland
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In:Journal of Alzheimer's Disease71:4, s. 1233-12431387-28771875-8908
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Luikku, Antti J.
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Hall, Anette
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Nerg, Ossi
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Koivisto, Anne M ...
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Hiltunen, Mikko
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Helisalmi, Seppo
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Herukka, Sanna-K ...
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Junkkari, Antti
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Sutela, Anna
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Kojoukhova, Mari ...
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Korhonen, Ville
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Mattila, Jussi
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Lötjönen, Jyrki
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Rummukainen, Jaa ...
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Alafuzoff, Irina
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Jääskeläinen, Ju ...
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Remes, Anne M.
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Solomon, Alina
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Kivipelto, Miia
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Soininena, Hilkk ...
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Rauramaa, Tuomas
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Leinonen, Ville
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Uppsala University
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