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Betulin wound gel a...
Betulin wound gel accelerated healing of superficial partial thickness burns : Results of a randomized, intra-individually controlled, phase III trial with 12-months follow-up
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- Frew, Quentin (author)
- Mid Essex Hosp Trust, Broomfield Hosp, St Andrews Ctr Plast Surg & Burns, Chelmsford, Essex, England
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- Rennekampff, Hans-Oliver (author)
- Rhein Maas Klinikum, Dept Plast Aesthet & Burn Surg, Wurselen, Germany
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- Dziewulski, Peter (author)
- Mid Essex Hosp Trust, Broomfield Hosp, St Andrews Ctr Plast Surg & Burns, Chelmsford, Essex, England
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- Moiem, Naiem (author)
- Univ Hosp Birmingham NHS Fdn Trust Queen Elisabet, Burns & Plast, Birmingham, W Midlands, England
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- Zahn, Tobias (author)
- Birken AG, Niefern Oschelbronn, Germany;3R Pharma Consulting GmbH, Dobel, Germany
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- Hartmann, Bernd (author)
- Unfallkrankenhaus Berlin, Burn Ctr Plast Surg, Berlin, Germany
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- Siemers, Frank (author)
- BG Kliniken Bergmannstrost, Klin Plast & Handchirurg Brandverletzten Zentrum, Halle, Germany
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- Mailander, Peter (author)
- Univ Lubeck, Klin Plast Chirurg Handchirurg, Intens Inheit Schwerbrandverletzte, Lubeck, Germany
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- Lehnhardt, Marcus (author)
- BG Univ Klin Bergmannsheil, Klin Plast Chirurg & Schwerbrandverletzte, Bochum, Germany
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- Thorfinn, Johan, 1970- (author)
- Linköpings universitet,Institutionen för klinisk och experimentell medicin,Medicinska fakulteten,Region Östergötland, Hand- och plastikkirurgiska kliniken US,BBW-11 Study Group
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- Huss, Fredrik, 1971- (author)
- Uppsala universitet,Plastikkirurgi
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- Pietramaggiori, Sandra Scherer (author)
- CHU Vaudois, Chirurg Plast & Reconstruct, Lausanne, Switzerland
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- Dheansa, Baljit (author)
- Queen Victoria Hosp NHS, Burn Ctr, E Grinstead, England
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- Metelmann, Hans-Robert (author)
- Univ Med Greifswald, Klin & Poliklin Mund Kiefer Gesichtschirurg Plast, Greifswald, Germany
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- Schumann, Hauke (author)
- Kathol Hsch Freiburg, Freiburg, Germany
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(creator_code:org_t)
- Elsevier, 2019
- 2019
- English.
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In: Burns. - : Elsevier. - 0305-4179 .- 1879-1409. ; 45:4, s. 876-890
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Objective: Acceleration of wound healing promises advantages for patients and caregivers in reducing the burden of disease, avoiding complications such as wound infections, and improving the long-term outcome. However, medicines that can accelerate wound healing are lacking. The objective of this open, blindly evaluated, randomized, multicenter phase III study was to compare intra-individually the efficacy and tolerability of Oleogel-S10 with fatty gauze dressing versus Octenilin (R) wound gel with fatty gauze dressing in accelerating the healing of superficial partial thickness burn wounds. Methods: Acute superficial partial thickness burn wounds in adults caused by fire, heat burn or scalding were divided into 2 halves and randomly assigned to treatment with Oleogel-S10 or Octenilin (R) wound gel. Photos for observer-blinded analysis of wound healing were taken at each wound dressing change. Percentages of reepithelialization were assessed at defined intervals. Efficacy and tolerability were evaluated based on a 5-point Likert scale. Results: Of 61 patients that were enrolled, 57 received the allocated intervention and 48 completed treatment. The percentage of patients with earlier wound healing was significantly higher for Oleogel-S10 (85.7%, n=30) compared to Octenilin (R) wound gel (14.3%, n= 5, p <0.0001). The mean intra-individual difference in time to wound closure was -1.0 day in favour of Oleogel-S10 (-1.4, -0.6; 95% CI, p <0.0001). Most investigators (87.0%) and patients (84.8%) evaluated the efficacy of Oleogel-S10 to be 'better' or 'much better' than that of Octenilin (R) wound gel. Long-term outcome 3 months and 12 months post injury was improved in some patients. Conclusions: Oleogel-S10 (Episalvan) significantly accelerated the healing of superficial partial thickness burn wounds. It was safe and well tolerated. (C) 2018 Elsevier Ltd and ISBI. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- Partial thickness wounds
- Grade 2a burns
- Superficial partial thickness burns
- Betulin
- Birch bark extract
- Randomized clinical trial
Publication and Content Type
- ref (subject category)
- art (subject category)
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Burns
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- By the author/editor
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Frew, Quentin
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Rennekampff, Han ...
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Dziewulski, Pete ...
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Moiem, Naiem
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Zahn, Tobias
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Hartmann, Bernd
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Siemers, Frank
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Mailander, Peter
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Lehnhardt, Marcu ...
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Thorfinn, Johan, ...
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Huss, Fredrik, 1 ...
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Pietramaggiori, ...
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Dheansa, Baljit
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Metelmann, Hans- ...
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Schumann, Hauke
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
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Burns
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Uppsala University
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Linköping University