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Radiation-Induced M...
Radiation-Induced Meningiomas After Childhood Brain Tumor : A Magnetic Resonance Imaging Screening Study
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- Remes, Tiina M. (author)
- Oulu Univ Hosp, Dept Pediat & Adolescence, PEDEGO Res Unit, Med Res Ctr, POB 28, Oulu 90029, Finland;Univ Oulu, POB 28, Oulu 90029, Finland
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- Suo-Palosaari, Maria H. (author)
- Univ Oulu, POB 28, Oulu 90029, Finland;Oulu Univ Hosp, Dept Diagnost Radiol, Oulu, Finland;Univ Oulu, Fac Med, Res Unit Med Imaging Phys & Technol, Oulu, Finland;Oulu Univ Hosp, Med Res Ctr Oulu, Oulu, Finland
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- Heikkilä, Vesa-Pekka (author)
- Oulu Univ Hosp, Dept Oncol & Radiotherapy, Oulu, Finland
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- Sutela, Anna K. (author)
- Kuopio Univ Hosp, Dept Clin Radiol, Kuopio, Finland
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- Koskenkorva, Päivi K. T. (author)
- Kuopio Univ Hosp, Dept Clin Radiol, Kuopio, Finland
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- Toiviainen-Salo, Sanna-Maria (author)
- Univ Helsinki, HUS Med Imaging Ctr, Dept Pediat Radiol, Helsinki, Finland;Helsinki Univ Hosp, Helsinki, Finland
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- Porra, Liisa (author)
- Helsinki Univ Hosp, Comprehens Canc Ctr, Dept Radiat Oncol, Helsinki, Finland
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- Arikoski, Pekka M. (author)
- Kuopio Univ Hosp, Dept Pediat & Adolescence, Kuopio, Finland;Univ Eastern Finland, Kuopio, Finland
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- Lähteenmäki, Päivi M. (author)
- Turku Univ Hosp, Dept Pediat & Adolescence, Turku, Finland;Turku Univ, Turku, Finland
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- Pokka, Tytti M-L (author)
- Oulu Univ Hosp, Dept Pediat & Adolescence, PEDEGO Res Unit, Med Res Ctr, POB 28, Oulu 90029, Finland;Univ Oulu, POB 28, Oulu 90029, Finland
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- Arola, Mikko O. (author)
- Tampere Univ Hosp, Dept Pediat & Adolescence, Tampere, Finland
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- Riikonen, V. Pekka (author)
- Kuopio Univ Hosp, Dept Pediat & Adolescence, Kuopio, Finland;Univ Eastern Finland, Kuopio, Finland
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- Sirkiä, Kirsti H. (author)
- Helsinki Univ Hosp, Dept Pediat & Adolescence, Helsinki, Finland
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- Lönnovist, Tuula R., I (author)
- Helsinki Univ Hosp, Helsinki, Finland;Univ Helsinki, Childrens Hosp, Dept Child Neurol, Helsinki, Finland
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- Rantala, Heikki M. J. (author)
- Oulu Univ Hosp, Dept Pediat & Adolescence, PEDEGO Res Unit, Med Res Ctr, POB 28, Oulu 90029, Finland;Univ Oulu, POB 28, Oulu 90029, Finland
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- Ojaniemi, Marja K. (author)
- Oulu Univ Hosp, Dept Pediat & Adolescence, PEDEGO Res Unit, Med Res Ctr, POB 28, Oulu 90029, Finland;Univ Oulu, POB 28, Oulu 90029, Finland
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- Harila-Saari, Arja H. (author)
- Uppsala universitet,Barnneurologi/Barnonkologi
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(creator_code:org_t)
- Mary Ann Liebert, 2019
- 2019
- English.
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In: Journal of Adolescent and Young Adult Oncology. - : Mary Ann Liebert. - 2156-5333 .- 2156-535X. ; 8:5, s. 593-601
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Purpose: Childhood brain tumors (CBTs) and their treatment increase the risk of secondary neoplasms (SNs). We studied the incidence of secondary craniospinal tumors with magnetic resonance imaging (MRI) screening in a national cohort of survivors of CBT treated with radiotherapy, and we analyzed the Finnish Cancer Registry (FCR) data on SNs in survivors of CBT with radiotherapy registered as a part of the primary tumor treatment. Methods: A total of 73 survivors of CBT participated in the MRI study (mean follow-up of 19 +/- 6.2 years). The incidence of SNs in a cohort of CBT patients (N = 569) was retrieved from the FCR (mean follow-up of 11 +/- 12.9 years). Brain tumors were diagnosed at age <= 16 years between the years 1970 and 2008 in the clinical study and the years 1963 and 2010 in the FCR population. Results: Secondary brain tumors, meningiomas in all and schwannoma in one, were found in 6 of the 73 (8.2%) survivors with a mean of 23 +/- 4.3 years after the diagnosis of the primary tumor. The cumulative incidence was 10.2% (95% confidence interval [CI] 3.9-25.1) in 25 years of follow-up. In the FCR data, the 25-year cumulative incidence of SNs was 2.4% (95% CI 1.3-4.1); only two brain tumors, no meningiomas, were registered. Conclusion: Survivors of CBT treated with radiotherapy have a high incidence of meningiomas, which are rarely registered in the FCR.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- secondary neoplasms
- meningiomas
- children
- brain tumors
- irradiation
- survivors
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Remes, Tiina M.
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Suo-Palosaari, M ...
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Heikkilä, Vesa-P ...
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Sutela, Anna K.
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Koskenkorva, Päi ...
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Toiviainen-Salo, ...
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show more...
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Porra, Liisa
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Arikoski, Pekka ...
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Lähteenmäki, Päi ...
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Pokka, Tytti M-L
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Arola, Mikko O.
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Riikonen, V. Pek ...
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Sirkiä, Kirsti H ...
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Lönnovist, Tuula ...
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Rantala, Heikki ...
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Ojaniemi, Marja ...
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Harila-Saari, Ar ...
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Uppsala University