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Interferon-gamma po...
Interferon-gamma potentiates GABA(A) receptor-mediated inhibitory currents in rat hippocampal CA1 pyramidal neurons
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- Flood, Louise (author)
- Uppsala universitet,Birnir: Molekylär fysiologi och neurovetenskap,louise.flood@neuro.uu.se
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- Korol, Sergiy (author)
- Uppsala universitet,Birnir: Molekylär fysiologi och neurovetenskap
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- Ekselius, Lisa (author)
- Uppsala universitet,Ekselius: Psykiatri,Uppsala Univ, Uppsala Univ Hosp, Dept Neurosci, Psychiat, Uppsala, Sweden
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- Birnir, Bryndis (author)
- Uppsala universitet,Birnir: Molekylär fysiologi och neurovetenskap
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- Jin, Zhe (author)
- Uppsala universitet,Birnir: Molekylär fysiologi och neurovetenskap,NingXia Med Univ, Dept Neurosurg, Gen Hosp, Ningxia, Peoples R China
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(creator_code:org_t)
- ELSEVIER, 2019
- 2019
- English.
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In: Journal of Neuroimmunology. - : ELSEVIER. - 0165-5728 .- 1872-8421. ; 337
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Abstract
Subject headings
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- The neural transmission and plasticity can be differentially modulated by various elements of the immune system. Interferon-gamma (IFN-gamma) is a "pro-inflammatory" cytokine mainly produced by T lymphocytes, activates its corresponding receptor and plays important roles under both homeostatic and inflammatory conditions. However, the impact of IFN-gamma on the gamma-aminobutyric acid (GABA)-mediated currents in the hippocampus, a major brain region involved in the cognitive function, has not been investigated. Here we detected abundant expression of both IFN-gamma receptor subunit gene transcripts (Ifngrl and Ifngr2) in the rat hippocampus by quantitative PCR. In addition, we pre-incubated rat hippocampal slices with IFN-gamma (100 ng/ml) and recorded GABA-activated spontaneous and miniature postsynaptic inhibitory currents (sIPSCs and mIPSCs) and tonic currents in hippocampal CAl pyramidal neurons by the whole-cell patch-clamp method. The pre-incubation with IFN-gamma increased the frequency but not the mean amplitude, rise time or decay time of both sIPSCs and mIPSCs in hippocampal CAl pyramidal neurons, suggesting a presynaptic effect of IFN-gamma. Moreover, the GABA-activated tonic currents were enhanced by IFN-gamma. In conclusion, the potentiation of GABAergic currents in hippocampal neurons by IFN-gamma may contribute to the disturbed neuronal excitability and cognitive dysfunction during neuroinflammation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- gamma-Aminobutyric acid
- Hippocampus
- Interferon-gamma
- Phasic inhibition
- Tonic inhibition
Publication and Content Type
- ref (subject category)
- art (subject category)
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