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Emotional Mental Im...
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Di Simplicio, MartinaImperial Coll London, Dept Brain Sci, Div Psychiat, London, England
(author)
Emotional Mental Imagery Abnormalities in Monozygotic Twins With, at High-Risk of, and Without Affective Disorders : Present in Affected Twins in Remission but Absent in High-Risk Twins
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Publisher, publication year, extent ...
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2019-11-08
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Frontiers Media S.A.2019
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-400112
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-400112URI
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https://doi.org/10.3389/fpsyt.2019.00801DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:142347430URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background: Mental imagery abnormalities feature across affective disorders including bipolar disorder (BD) and unipolar depression (UD). Maladaptive emotional imagery has been proposed as a maintenance factor for affective symptomatology and a target for mechanism-driven psychological treatment developments. Where imagery abnormalities feature beyond acute affective episodes, further opportunities for innovation arise beyond treatments, such as for tertiary/relapse prevention (e.g., in remitted individuals) or primary prevention (e.g., in non-affected but at-risk individuals). The aim of our study was to investigate for the first time the presence of possible mental imagery abnormalities in affected individuals in remission and at-risk individuals for affective disorders using a familial risk design. Methods: A population-based cohort of monozygotic twins was recruited through linkage between the Danish national registries (N=204). Participants were grouped as: affected (remitted BD/UD; n = 115); high-risk (co-twin with history of BD/UD; n = 49), or low-risk (no co-twin history of BD/UD; n = 40). Twins completed mental imagery measures spanning key subjective domains (spontaneous imagery use and emotional imagery) and cognitive domains (imagery inspection and imagery manipulation). Results: Affected twins in remission reported enhanced emotional mental imagery compared to both low- and high-risk twins. This was characterized by greater impact of i) intrusive prospective imagery (Impact of Future Events Scale) and ii) deliberately-generated prospective imagery of negative scenarios (Prospective Imagery Task). There were no significant differences in these key measures between affected BD and UD twins in remission. Additionally, low- and high-risk twins did not significantly differ on these emotional imagery measures. There were also no significant differences between the three groups on non-emotional measures including spontaneous imagery use and cognitive stages of imagery. Conclusions: Abnormalities in emotional prospective imagery are present in monozygotic twins with affective disorders in remission-despite preserved cognitive stages of imagery-but absent in unaffected high-risk twins, and thus do not appear to index familial risk (i.e., unlikely to qualify as "endophenotypes"). Elevated emotional prospective imagery represents a promising treatment/prevention target in affective disorders.
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Lau-Zhu, AlexImperial Coll London, Dept Brain Sci, Div Psychiat, London, England;Kings Coll London, Inst Psychiat Psychol & Neurosci, Social Genet & Dev Psychiat Ctr, London, England;Univ Oxford, Oxford Inst Clin Psychol Training, Med Sci Div, Oxford, England
(author)
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Meluken, IselinCopenhagen Univ Hosp, Rigshosp, Psychiat Ctr Copenhagen, Copenhagen Affect Disorder Res Ctr CADIC, Copenhagen, Denmark
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Taylor, PatrickImperial Coll London, Dept Brain Sci, Div Psychiat, London, England
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Kessing, Lars VedelCopenhagen Univ Hosp, Rigshosp, Psychiat Ctr Copenhagen, Copenhagen Affect Disorder Res Ctr CADIC, Copenhagen, Denmark
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Vinberg, MajCopenhagen Univ Hosp, Rigshosp, Psychiat Ctr Copenhagen, Copenhagen Affect Disorder Res Ctr CADIC, Copenhagen, Denmark
(author)
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Holmes, Emily AlexandraKarolinska Institutet,Uppsala universitet,Institutionen för psykologi,Karolinska Inst, Dept Clin Neurosci, Div Psychol, Stockholm, Sweden(Swepub:uu)emiho252
(author)
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Miskowiak, Kamilla WoznicaCopenhagen Univ Hosp, Rigshosp, Psychiat Ctr Copenhagen, Copenhagen Affect Disorder Res Ctr CADIC, Copenhagen, Denmark;Univ Copenhagen, Dept Psychol, Copenhagen, Denmark
(author)
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Imperial Coll London, Dept Brain Sci, Div Psychiat, London, EnglandImperial Coll London, Dept Brain Sci, Div Psychiat, London, England;Kings Coll London, Inst Psychiat Psychol & Neurosci, Social Genet & Dev Psychiat Ctr, London, England;Univ Oxford, Oxford Inst Clin Psychol Training, Med Sci Div, Oxford, England
(creator_code:org_t)
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In:Frontiers in Psychiatry: Frontiers Media S.A.101664-0640
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