Search: onr:"swepub:oai:DiVA.org:uu-400460" >
High genetic risk s...
High genetic risk score is associated with early disease onset, damage accrual and decreased survival in systemic lupus erythematosus
-
- Reid, Sarah (author)
- Uppsala University,Uppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab
-
- Alexsson, Andrei (author)
- Uppsala University,Uppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab
-
- Frodlund, Martina (author)
- Linköping University,Rheumatology/Division of Neuro and Inflammation Sciences, Department of Clinical and Experimental Medicine, Linköping University, Linkoping, Sweden
-
show more...
-
- Morris, David (author)
- Department of Medical and Molecular Genetics, King’s College London, London, UK
-
- Sandling, Johanna K. (author)
- Uppsala University,Uppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab
-
- Bolin, Karin (author)
- Uppsala University,Uppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab
-
- Svenungsson, Elisabet (author)
- Karolinska Institutet,Karolinska Institute,Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
-
- Jönsen, Andreas (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Rheumatology, Department of Clinical Sciences, Lund University, Lund, Sweden
-
- Bengtsson, Christine (author)
- Umeå University,Umeå universitet,Reumatologi,Department of Public Health and Clinical Medicine/Rheumatology, Umeå University, Umeå, Sweden
-
- Gunnarsson, Iva (author)
- Karolinska Institutet,Karolinska Institute,Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
-
- Illescas Rodriguez, Vera (author)
- Karolinska Institute,Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
-
- Bengtsson, Anders (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Rheumatology, Department of Clinical Sciences, Lund University, Lund, Sweden
-
- Arve, Sabine (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Rheumatology, Department of Clinical Sciences, Lund University, Lund, Sweden
-
- Rantapää-Dahlqvist, Solbritt (author)
- Umeå University,Umeå universitet,Reumatologi,Department of Public Health and Clinical Medicine/Rheumatology, Umeå University, Umeå, Sweden
-
- Eloranta, Maija-Leena (author)
- Uppsala University,Uppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab
-
- Syvänen, Ann-Christine, 1950- (author)
- Uppsala University,Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab
-
- Sjöwall, Christopher (author)
- Linköping University,Rheumatology/Division of Neuro and Inflammation Sciences, Department of Clinical and Experimental Medicine, Linköping University, Linkoping, Sweden
-
- Vyse, Timothy James (author)
- Department of Medical and Molecular Genetics, King’s College London, London, UK
-
- Rönnblom, Lars (author)
- Uppsala University,Uppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab
-
- Leonard, Dag, 1975- (author)
- Uppsala University,Uppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab
-
show less...
-
(creator_code:org_t)
- 2019-12-11
- 2020
- English.
-
In: Annals of the Rheumatic Diseases. - : BMJ Publishing Group Ltd. - 0003-4967 .- 1468-2060. ; 79:3, s. 363-369
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://uu.diva-port... (primary) (Raw object)
-
https://ard.bmj.com/...
-
https://umu.diva-por... (primary) (Raw object)
-
http://dx.doi.org/10... (free)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
https://lup.lub.lu.s...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- OBJECTIVES: To investigate associations between a high genetic disease risk and disease severity in patients with systemic lupus erythematosus (SLE).METHODS: Patients with SLE (n=1001, discovery cohort and n=5524, replication cohort) and healthy controls (n=2802 and n=9859) were genotyped using a 200K Immunochip single nucleotide polymorphism array. A genetic risk score (GRS) was assigned to each individual based on 57 SLE risk loci.RESULTS: SLE was more prevalent in the high, compared with the low, GRS-quartile (OR 12.32 (9.53 to 15.71), p=7.9×10-86 and OR 7.48 (6.73 to 8.32), p=2.2×10-304 for the discovery and the replication cohorts, respectively). In the discovery cohort, patients in the high GRS-quartile had a 6-year earlier mean disease onset (HR 1.47 (1.22 to 1.75), p=4.3×10-5), displayed higher prevalence of damage accrual (OR 1.47 (1.06 to 2.04), p=2.0×10-2), renal disorder (OR 2.22 (1.50 to 3.27), p=5.9×10-5), anti-dsDNA (OR 1.83 (1.19 to 2.81), p=6.1×10-3), end-stage renal disease (ESRD) (OR 5.58 (1.50 to 20.79), p=1.0×10-2), proliferative nephritis (OR 2.42 (1.30 to 4.49), p=5.1×10-3), anti-cardiolipin-IgG (OR 1.89 (1.13 to 3.18), p=1.6×10-2), anti-β2-glycoprotein-I-IgG (OR 2.29 (1.29 to 4.06), p=4.8×10-3) and positive lupus anticoagulant test (OR 2.12 (1.16 to 3.89), p=1.5×10-2) compared with patients in the low GRS-quartile. Survival analysis showed earlier onset of the first organ damage (HR 1.51 (1.04 to 2.25), p=3.7×10-2), first cardiovascular event (HR 1.65 (1.03 to 2.64), p=2.6×10-2), nephritis (HR 2.53 (1.72 to 3.71), p=9.6×10-7), ESRD (HR 6.78 (1.78 to 26.86), p=6.5×10-3) and decreased overall survival (HR 1.83 (1.02 to 3.30), p=4.3×10-2) in high to low quartile comparison.CONCLUSIONS: A high GRS is associated with increased risk of organ damage, renal dysfunction and all-cause mortality. Our results indicate that genetic profiling may be useful for predicting outcomes in patients with SLE.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- antiphospholipid syndrome
- cardiovascular disease
- gene polymorphism
- lupus nephritis
- systemic lupus erythematosus
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Reid, Sarah
-
Alexsson, Andrei
-
Frodlund, Martin ...
-
Morris, David
-
Sandling, Johann ...
-
Bolin, Karin
-
show more...
-
Svenungsson, Eli ...
-
Jönsen, Andreas
-
Bengtsson, Chris ...
-
Gunnarsson, Iva
-
Illescas Rodrigu ...
-
Bengtsson, Ander ...
-
Arve, Sabine
-
Rantapää-Dahlqvi ...
-
Eloranta, Maija- ...
-
Syvänen, Ann-Chr ...
-
Sjöwall, Christo ...
-
Vyse, Timothy Ja ...
-
Rönnblom, Lars
-
Leonard, Dag, 19 ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Rheumatology and ...
- Articles in the publication
-
Annals of the Rh ...
- By the university
-
Uppsala University
-
Umeå University
-
Lund University
-
Karolinska Institutet