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DNA methylation pro...
DNA methylation profiles in chronic lymphocytic leukemia patients treated with chemoimmunotherapy
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- Tsagiopoulou, Maria (author)
- Ctr Res & Technol Hellas, Inst Appl Biosci, 6th Km Charilaou Thermi Rd, Thessaloniki 57001, GR, Greece;Univ Athens, Dept Biol, Athens, Greece
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- Papakonstantinou, Nikos (author)
- Ctr Res & Technol Hellas, Inst Appl Biosci, 6th Km Charilaou Thermi Rd, Thessaloniki 57001, GR, Greece
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- Moysiadis, Theodoros (author)
- Karolinska Institutet
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- Mansouri, Larry (author)
- Karolinska Institutet,Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi,Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden
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- Ljungström, Viktor, 1986- (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Experimentell och klinisk onkologi
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- Duran-Ferrer, Marti (author)
- Univ Barcelona, Inst Invest Biomed August Pi i Sunyer IDIBAPS, Dept Fundamentos Clin, Barcelona, Spain
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- Malousi, Andigoni (author)
- Aristotle Univ Thessaloniki, Med Sch, Lab Biol Chem, Thessaloniki, Greece
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- Queiros, Ana C. (author)
- Univ Barcelona, Inst Invest Biomed August Pi i Sunyer IDIBAPS, Dept Fundamentos Clin, Barcelona, Spain
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- Plevova, Karla (author)
- Univ Hosp Brno, Dept Internal Med Hematol & Oncol, Brno, Czech Republic;Masaryk Univ, Med Fac, Brno, Czech Republic;Masaryk Univ, Cent European Inst Technol, Brno, Czech Republic
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- Bhoi, Sujata (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab
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- Kollia, Panagoula (author)
- Univ Athens, Dept Biol, Athens, Greece
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- Oscier, David (author)
- Royal Bournemouth Hosp, Dept Haematol, Bournemouth, Dorset, England
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- Anagnostopoulos, Achilles (author)
- G Papanicolaou Hosp, Hematol Dept, Thessaloniki, Greece;G Papanicolaou Hosp, HCT Unit, Thessaloniki, Greece
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- Trentin, Livio (author)
- Univ Padua, Sch Med, Dept Med, Hematol & Clin Immunol Branch, Padua, Italy
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- Ritgen, Matthias (author)
- Univ Hosp Schleswig Holstein, Med Dept 2, Campus Kiel, Kiel, Germany
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- Pospisilova, Sarka (author)
- Univ Hosp Brno, Dept Internal Med Hematol & Oncol, Brno, Czech Republic;Masaryk Univ, Med Fac, Brno, Czech Republic;Masaryk Univ, Cent European Inst Technol, Brno, Czech Republic
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- Stavroyianni, Niki (author)
- G Papanicolaou Hosp, Hematol Dept, Thessaloniki, Greece;G Papanicolaou Hosp, HCT Unit, Thessaloniki, Greece
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- Ghia, Paolo (author)
- IRCCS San Raffaele Sci Inst, Div Expt Oncol, Milan, Italy;IRCCS San Raffaele Sci Inst, Dept Oncohematol, Milan, Italy;Univ Vita Salute San Raffaele, Milan, Italy
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- Martin-Subero, Jose I. (author)
- Univ Barcelona, Inst Invest Biomed August Pi i Sunyer IDIBAPS, Dept Fundamentos Clin, Barcelona, Spain;ICREA, Barcelona, Spain
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- Pott, Christiane (author)
- Univ Hosp Schleswig Holstein, Med Dept 2, Campus Kiel, Kiel, Germany
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- Rosenquist, Richard (author)
- Karolinska Institutet
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- Stamatopoulos, Kostas (author)
- Ctr Res & Technol Hellas, Inst Appl Biosci, 6th Km Charilaou Thermi Rd, Thessaloniki 57001, GR, Greece;Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden
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(creator_code:org_t)
- 2019-12-02
- 2019
- English.
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In: Clinical Epigenetics. - : BMC. - 1868-7083 .- 1868-7075. ; 11
- Related links:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://clinicalepig...
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Abstract
Subject headings
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- Background: In order to gain insight into the contribution of DNA methylation to disease progression of chronic lymphocytic leukemia (CLL), using 450K Illumina arrays, we determined the DNA methylation profiles in paired pre-treatment/relapse samples from 34 CLL patients treated with chemoimmunotherapy, mostly (n = 31) with the fludarabine-cyclophosphamide-rituximab (FCR) regimen.Results: The extent of identified changes in CLL cells versus memory B cells from healthy donors was termed "epigenetic burden" (EB) whereas the number of changes between the pre-treatment versus the relapse sample was termed "relapse changes" (RC). Significant (p < 0.05) associations were identified between (i) high EB and short time-to-first-treatment (TTFT); and, (ii) few RCs and short time-to-relapse. Both the EB and the RC clustered in specific genomic regions and chromatin states, including regulatory regions containing binding sites of transcription factors implicated in B cell and CLL biology.Conclusions: Overall, we show that DNA methylation in CLL follows different dynamics in response to chemoimmunotherapy. These epigenetic alterations were linked with specific clinical and biological features.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- DNA methylation
- Chemoimmunotherapy
- CLL
- Microarray analysis
- Relapse
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Tsagiopoulou, Ma ...
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Papakonstantinou ...
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Moysiadis, Theod ...
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Mansouri, Larry
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Ljungström, Vikt ...
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Duran-Ferrer, Ma ...
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show more...
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Malousi, Andigon ...
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Queiros, Ana C.
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Plevova, Karla
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Bhoi, Sujata
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Kollia, Panagoul ...
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Oscier, David
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Anagnostopoulos, ...
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Trentin, Livio
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Ritgen, Matthias
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Pospisilova, Sar ...
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Stavroyianni, Ni ...
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Ghia, Paolo
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Martin-Subero, J ...
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Pott, Christiane
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Rosenquist, Rich ...
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Stamatopoulos, K ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Clinical Epigene ...
- By the university
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Uppsala University
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Karolinska Institutet