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Highly Porous Amorp...
Highly Porous Amorphous Calcium Phosphate for Drug Delivery and Bio-Medical Applications
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- Sun, Rui (author)
- Uppsala universitet,Nanoteknologi och funktionella material
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- Åhlén, Michelle (author)
- Uppsala universitet,Nanoteknologi och funktionella material,Nanotechnology and Functional Materials
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- Tai, Cheuk-Wai (author)
- Stockholms universitet,Institutionen för material- och miljökemi (MMK),Department of Materials and Environmental Chemistry, Stockholm University, SE-106 91 Stockholm, Sweden
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- Bajnóczi, Eva G. (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för Molekylära vetenskaper,Department of Molecular Sciences
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- de Kleijne, Fenne (author)
- Uppsala universitet,Nanoteknologi och funktionella material
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- Ferraz, Natalia, 1976- (author)
- Uppsala universitet,Nanoteknologi och funktionella material
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- Persson, Ingmar (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för Molekylära vetenskaper,Department of Molecular Sciences
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- Strömme, Maria, 1970- (author)
- Uppsala universitet,Nanoteknologi och funktionella material
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- Cheung, Ocean (author)
- Uppsala universitet,Nanoteknologi och funktionella material
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(creator_code:org_t)
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- 2019-12-19
- 2020
- English.
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In: Nanomaterials. - : MDPI. - 2079-4991. ; 10:1
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Abstract
Subject headings
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- Amorphous calcium phosphate (ACP) has shown significant effects on the biomineralization and promising applications in bio-medicine. However, the limited stability and porosity of ACP material restrict its practical applications. A storage stable highly porous ACP with Brunauer–Emmett–Teller surface area of over 400 m2/g was synthesized by introducing phosphoric acid to a methanol suspension containing amorphous calcium carbonate nanoparticles. Electron microscopy revealed that the porous ACP was constructed with aggregated ACP nanoparticles with dimensions of several nanometers. Large angle X-ray scattering revealed a short-range atomic order of <20 Å in the ACP nanoparticles. The synthesized ACP demonstrated long-term stability and did not crystallize even after storage for over 14 months in air. The stability of the ACP in water and an α-MEM cell culture medium were also examined. The stability of ACP could be tuned by adjusting its chemical composition. The ACP synthesized in this work was cytocompatible and acted as drug carriers for the bisphosphonate drug alendronate (AL) in vitro. AL-loaded ACP released 25% of the loaded AL in the first 22 days. These properties make ACP a promising candidate material for potential application in biomedical fields such as drug delivery and bone healing.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Nanoteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Nano-technology (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Materialteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Materials Engineering (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Nanoteknik -- Nanoteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Nano-technology -- Nano-technology (hsv//eng)
Keyword
- amorphous calcium phosphate
- porous materials
- cytocompatibility
- drug carrier
- bisphosphonate
- Teknisk fysik med inriktning mot nanoteknologi och funktionella material
- Engineering Science with specialization in Nanotechnology and Functional Materials
- Teknisk fysik med inriktning mot nanoteknologi och funktionella material
- Engineering Science with specialization in Nanotechnology and Functional Materials
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Sun, Rui
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Åhlén, Michelle
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Tai, Cheuk-Wai
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Bajnóczi, Eva G.
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de Kleijne, Fenn ...
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Ferraz, Natalia, ...
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show more...
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Persson, Ingmar
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Strömme, Maria, ...
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Cheung, Ocean
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- About the subject
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Nano technology
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Materials Engine ...
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Nano technology
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and Nano technology
- Articles in the publication
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Nanomaterials
- By the university
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Uppsala University
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Stockholm University
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Swedish University of Agricultural Sciences