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Invited Review: Pat...
Invited Review: Pathology of pituitary neuroendocrine tumours : present status, modern diagnostic approach, controversies and future perspectives from a neuropathological and clinical standpoint
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- Manojlovic-Gacic, E (author)
- Institute of Pathology, School of Medicine, University of Belgrade, Belgrade, Serbia
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- Bollerslev, J (author)
- Section of Specialized Endocrinology, Department of Endocrinology, Oslo University Hospital Rikshospitalet, Oslo, Norway; Faculty of Medicine, University of Oslo, Oslo, Norway
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- Casar Borota, Olivera (author)
- Uppsala universitet,Klinisk och experimentell patologi,Department of Clinical Pathology, Uppsala University Hospital, Uppsala, Sweden
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(creator_code:org_t)
- 2019-07
- 2020
- English.
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In: Neuropathology and Applied Neurobiology. - : Wiley. - 0305-1846 .- 1365-2990. ; 46:2, s. 89-110
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Abstract
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- Neuroendocrine tumours of the adenohypophysis have traditionally been designated as pituitary adenomas to underline their usually indolent growth and lack of metastatic potential. However, they may demonstrate a huge spectrum of growth patterns and endocrine disturbances, some of them significantly affecting health and quality of life. To predict tumour growth, risk of postoperative recurrence and response to medical therapy in patients with pituitary neuroendocrine tumours is challenging. A thorough histopathological and immunohistochemical diagnostic work-up is an obligatory part of a multidisciplinary effort to precisely define the tumour type and assess prognostic and predictive factors on an individual basis. In this review, we have summarized the current status in the pathology in pituitary neuroendocrine tumours based on the selection of references from the PubMed database. We have presented possible diagnostic approaches according to the current pituitary cell lineage-based classification. The importance of recognizing histological subtypes with potentially aggressive behaviour and identification of prognostic and predictive tissue biomarkers have been highlighted. Controversies related to particular subtypes of pituitary tumours and a still limited prognostic impact of the current classification indicate the need for further refinement. Multidisciplinary approach including clinical, pathological and molecular genetic characterization will be essential for improved personalized therapy and the search for novel therapeutic targets in patients with pituitary neuroendocrine tumours.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Keyword
- diagnostic approach
- pituitary adenoma
- pituitary neuroendocrine tumour
- predictive markers
- prognostic markers
- transcription factors
- Patologi
- Pathology
Publication and Content Type
- ref (subject category)
- for (subject category)
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