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The polyamine transporter Slc18b1(VPAT) is important for both short and long time memory and for regulation of polyamine content in the brain.

Fredriksson, Robert (author)
Uppsala universitet,Institutionen för farmaceutisk biovetenskap
Sreedharan, Smitha, 1981- (author)
Uppsala universitet,Schiöth: Funktionell farmakologi,Neuroonkologi
Nordenankar, Karin, 1981- (author)
Uppsala universitet,Institutionen för neurovetenskap
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Alsiö, Johan (author)
Uppsala universitet,Schiöth: Funktionell farmakologi
Lindberg, Frida A. (author)
Uppsala universitet,Institutionen för farmaceutisk biovetenskap
Hutchinson, Ashley (author)
Uppsala universitet,Schiöth: Funktionell farmakologi
Eriksson, Anders (author)
Uppsala universitet,Schiöth: Funktionell farmakologi
Roshanbin, Sahar, 1984- (author)
Uppsala universitet,Schiöth: Funktionell farmakologi
Ciuculete, Diana M (author)
Uppsala universitet,Schiöth: Funktionell farmakologi
Klockars, Anica (author)
Uppsala universitet,Schiöth: Funktionell farmakologi
Todkar, Aniruddha (author)
Uppsala universitet,Schiöth: Funktionell farmakologi
Hägglund, Maria G (author)
Hellsten, Sofie V (author)
Uppsala universitet,Institutionen för farmaceutisk biovetenskap
Hindlycke, Viktoria (author)
Uppsala universitet,Schiöth: Funktionell farmakologi
Västermark, Åke, 1980- (author)
Uppsala universitet,Schiöth: Funktionell farmakologi
Shevchenko, Ganna (author)
Uppsala universitet,Analytisk kemi
Olivo, Gaia, MD, 1989- (author)
Uppsala universitet,Schiöth: Funktionell farmakologi
K, Cheng (author)
Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för Molekylära vetenskaper,Department of Molecular Sciences
Kullander, Klas, 1966- (author)
Uppsala universitet,Institutionen för neurovetenskap,Schiöth: Funktionell farmakologi
Moazzami, Ali (author)
Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för Molekylära vetenskaper,Department of Molecular Sciences
Bergquist, Jonas (author)
Uppsala universitet,Analytisk kemi
Olszewski, Pawel K. (author)
Uppsala universitet,Schiöth: Funktionell farmakologi
Schiöth, Helgi B. (author)
Uppsala universitet,Schiöth: Funktionell farmakologi
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 (creator_code:org_t)
 
2019-12-04
2019
English.
In: PLOS Genetics. - : Public Library of Science (PLoS). - 1553-7390 .- 1553-7404. ; 15:12
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • SLC18B1 is a sister gene to the vesicular monoamine and acetylcholine transporters, and the only known polyamine transporter, with unknown physiological role. We reveal that Slc18b1 knock out mice has significantly reduced polyamine content in the brain providing the first evidence that Slc18b1 is functionally required for regulating polyamine levels. We found that this mouse has impaired short and long term memory in novel object recognition, radial arm maze and self-administration paradigms. We also show that Slc18b1 KO mice have altered expression of genes involved in Long Term Potentiation, plasticity, calcium signalling and synaptic functions and that expression of components of GABA and glutamate signalling are changed. We further observe a partial resistance to diazepam, manifested as significantly lowered reduction in locomotion after diazepam treatment. We suggest that removal of Slc18b1 leads to reduction of polyamine contents in neurons, resulting in reduced GABA signalling due to long-term reduction in glutamatergic signalling.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)

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