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Circulating Tissue ...
Circulating Tissue Factor-Positive Procoagulant Microparticles in Patients with Type 1 Diabetes
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- Zhang, Chenghui (author)
- Sichuan Univ, West China Hosp, Dept Endocrinol & Metab, 37 Guoxue Rd, Chengdu 610041, Sichuan, Peoples R China;Peoples Govt Tibetan Autonomous Reg, Hosp Chengdu Off, Dept Endocrinol & Metab, Chengdu 610041, Sichuan, Peoples R China
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- Ou, Qing (author)
- Sichuan Univ, West China Hosp, Dept Endocrinol & Metab, 37 Guoxue Rd, Chengdu 610041, Sichuan, Peoples R China
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- Gu, Yan (author)
- Sichuan Univ, West China Hosp, Dept Endocrinol & Metab, 37 Guoxue Rd, Chengdu 610041, Sichuan, Peoples R China
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- Cheng, Gaiping (author)
- Sichuan Univ, West China Hosp, Dept Clin Nutr, Chengdu 610041, Sichuan, Peoples R China
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- Du, Rong (author)
- Sichuan Univ, West China Hosp, Dept Endocrinol & Metab, 37 Guoxue Rd, Chengdu 610041, Sichuan, Peoples R China;Peoples Govt Tibetan Autonomous Reg, Hosp Chengdu Off, Dept Endocrinol & Metab, Chengdu 610041, Sichuan, Peoples R China
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- Yuan, Li (author)
- Sichuan Univ, West China Hosp, Dept Endocrinol & Metab, 37 Guoxue Rd, Chengdu 610041, Sichuan, Peoples R China
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- Cordiner, Ruth L. M. (author)
- Univ Dundee, Ninewells Hosp, Div Populat Hlth & Genom, Dundee DD1 9SY, Scotland;Univ Dundee, Sch Med, Dundee DD1 9SY, Scotland
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- Kang, Deying (author)
- Sichuan Univ, West China Hosp, Chinese Evidence Based Med Ctr, Chengdu 610041, Sichuan, Peoples R China
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- Zhang, Jiaying (author)
- Sichuan Univ, West China Hosp, Dept Ophthalmol, Chengdu 610041, Sichuan, Peoples R China
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- Huang, Qiaorong (author)
- Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Lab Stem Cell Biol, 37 Guoxue Rd, Chengdu 610041, Sichuan, Peoples R China
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- Yu, Chuan (author)
- Sichuan Univ, West China Sch Publ Hlth, Dept Hlth Related Social & Behav Sci, Chengdu 610041, Sichuan, Peoples R China
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- Kang, Li (author)
- Univ Dundee, Sch Med, Dundee DD1 9SY, Scotland;Univ Dundee, Ninewells Hosp, Div Syst Med, Dundee DD1 9SY, Scotland
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- Wang, Xuan, 1984- (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Science for Life Laboratory, SciLifeLab,Univ Dundee, Ninewells Hosp, Div Populat Hlth & Genom, Dundee DD1 9SY, Scotland;Univ Dundee, Sch Med, Dundee DD1 9SY, Scotland
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- Sun, Xin (author)
- Sichuan Univ, West China Hosp, Chinese Evidence Based Med Ctr, Chengdu 610041, Sichuan, Peoples R China
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- Mo, Xianming (author)
- Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Lab Stem Cell Biol, 37 Guoxue Rd, Chengdu 610041, Sichuan, Peoples R China
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- Tian, Haoming (author)
- Sichuan Univ, West China Hosp, Dept Endocrinol & Metab, 37 Guoxue Rd, Chengdu 610041, Sichuan, Peoples R China
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- Pearson, Ewan R. (author)
- Univ Dundee, Ninewells Hosp, Div Populat Hlth & Genom, Dundee DD1 9SY, Scotland;Univ Dundee, Sch Med, Dundee DD1 9SY, Scotland
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- Meng, Wentong (author)
- Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Lab Stem Cell Biol, 37 Guoxue Rd, Chengdu 610041, Sichuan, Peoples R China
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- Li, Sheyu (author)
- Sichuan Univ, West China Hosp, Dept Endocrinol & Metab, 37 Guoxue Rd, Chengdu 610041, Sichuan, Peoples R China;Univ Dundee, Ninewells Hosp, Div Populat Hlth & Genom, Dundee DD1 9SY, Scotland;Univ Dundee, Sch Med, Dundee DD1 9SY, Scotland
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(creator_code:org_t)
- DOVE MEDICAL PRESS LTD, 2019
- 2019
- English.
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In: Diabetes, Metabolic Syndrome and Obesity. - : DOVE MEDICAL PRESS LTD. - 1178-7007. ; 12, s. 2819-2828
- Related links:
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https://doi.org/10.2...
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https://uu.diva-port... (primary) (Raw object)
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Abstract
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- Aim: To investigate the count of circulating tissue factor-positive (TF+) procoagulant microparticles (MPs) in patients with type 1 diabetes mellitus (T1DM).Methods: This case-control study included patients with T1DM and age and sex-matched healthy volunteers. The counts of phosphatidylserine-positive (PS+) MPs and TF(+)PS(+)MPs and the subgroups derived from different cell types were measured in the peripheral blood sample of the two groups using multicolor flow cytometric assay. We compared the counts of each MP between groups as well as the ratio of the TF(+)PS(+)MPs and PS(+)MPs (TF(+)PS(+)MPs/PS(+)MPs).Results: We recruited 36 patients with T1DM and 36 matched healthy controls. Compared with healthy volunteers, PS(+)MPs, TF(+)PS(+)MPs and TF(+)PS(+)MPs/PS(+)MPs were elevated in patients with T1DM (PS(+)MPs: 1078.5 +/- 158.08 vs 686.84 +/- 122.04/mu L, P <0.001; TF(+)PS(+)MPs: 202.10 +/- 47.47 vs 108.33 +/- 29.42/mu L, P <0.001; and TF(+)PS(+)MPs/PS(+)MPs: 0.16 +/- 0.04 vs 0.19 +/- 0.05, P = 0.004), mostly derived from platelet, lymphocytes and endothelial cells. In the subgroup analysis, the counts of total and platelet TF(+)PS(+)MPs were increased in patients with diabetic retinopathy (DR) and with higher HbA1c, respectively.Conclusion: Circulating TF(+)PS(+)MPs and those derived from platelet, lymphocytes and endothelial cells were elevated in patients with T1DM.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- type 1 diabetes mellitus
- microparticles
- tissue factor
- diabetic retinopathy
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Zhang, Chenghui
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Ou, Qing
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Gu, Yan
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Cheng, Gaiping
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Du, Rong
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Yuan, Li
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Cordiner, Ruth L ...
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Kang, Deying
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Zhang, Jiaying
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Huang, Qiaorong
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Yu, Chuan
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Kang, Li
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Wang, Xuan, 1984 ...
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Sun, Xin
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Mo, Xianming
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Tian, Haoming
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Pearson, Ewan R.
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Meng, Wentong
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Li, Sheyu
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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Diabetes, Metabo ...
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Uppsala University