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PD-L1 and IDO1 are ...
PD-L1 and IDO1 are potential targets for treatment in patients with primary diffuse large B-cell lymphoma of the CNS
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- Abdulla, Maysaa (author)
- Uppsala universitet,Klinisk och experimentell patologi,Rose-Marie Amini
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- Alexsson, Andrei (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi
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- Sundström, Christer (author)
- Uppsala universitet,Klinisk och experimentell patologi,Rose-Marie Amini
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- Ladenvall, Claes, PhD, 1974- (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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- Mansouri, Larry (author)
- Karolinska Institutet,Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
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- Lindskog, Cecilia (author)
- Uppsala universitet,Klinisk och experimentell patologi
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- Berglund, Mattias (author)
- Uppsala universitet,Experimentell och klinisk onkologi
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- Cavelier, Lucia (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik
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- Enblad, Gunilla (author)
- Uppsala universitet,Experimentell och klinisk onkologi
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- Hollander, Peter (author)
- Uppsala universitet,Klinisk och experimentell patologi,Rose-Marie Amini
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- Amini, Rose-Marie (author)
- Uppsala universitet,Klinisk och experimentell patologi,Rose-Marie Amini
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(creator_code:org_t)
- Taylor & Francis, 2021
- 2021
- English.
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In: Acta Oncologica. - : Taylor & Francis. - 0284-186X .- 1651-226X. ; 60:4, s. 531-538
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Abstract
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- BackgroundProgrammed cell death 1 (PD-1) and its ligands PD-L1 and PD-L2, as well as Indoleamine 2,3-deoxygenase (IDO1) can be expressed both by tumor and microenvironmental cells and are crucial for tumor immune escape. We aimed to evaluate the role of PD-1, its ligands and IDO1 in a cohort of patients with primary diffuse large B-cell lymphoma of the CNS (PCNSL).Material and methodsTissue microarrays (TMAs) were constructed in 45 PCNSL cases. RNA extraction from whole tissue sections and RNA sequencing were successfully performed in 33 cases. Immunohistochemical stainings for PD-1, PD-L1/paired box protein 5 (PAX-5), PD-L2/PAX-5 and IDO1, and Epstein-Barr virus encoding RNA (EBER) in situ hybridization were analyzed.ResultsHigh proportions of PD-L1 and PD-L2 positive tumor cells were observed in 11% and 9% of cases, respectively. High proportions of PD-L1 and PD-L2 positive leukocytes were observed in 55% and 51% of cases, respectively. RNA sequencing revealed that gene expression of IDO1 was high in patients with high proportion of PD-L1 positive leukocytes (p = .01). Protein expression of IDO1 in leukocytes was detected in 14/45 cases, in 79% of these cases a high proportion of PD-L1 positive leukocytes was observed. Gene expression of IDO1 was high in EBER-positive cases (p = .0009) and protein expression of IDO1 was detected in five of six EBER-positive cases.ConclusionOur study shows a significant association between gene and protein expression of IDO1 and protein expression of PD-L1 in the tumor microenvironment of PCNSL, possibly of importance for prediction of response to immunotherapies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Keyword
- PCNSL
- PD-1
- PD-L1
- PD-L2
- IDO1
- EBER
- Pathology
- Patologi
- Pathology
- Patologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Abdulla, Maysaa
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Alexsson, Andrei
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Sundström, Chris ...
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Ladenvall, Claes ...
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Mansouri, Larry
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Lindskog, Cecili ...
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show more...
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Berglund, Mattia ...
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Cavelier, Lucia
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Enblad, Gunilla
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Hollander, Peter
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Amini, Rose-Mari ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Clinical Laborat ...
- Articles in the publication
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Acta Oncologica
- By the university
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Uppsala University
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Karolinska Institutet