Search: onr:"swepub:oai:DiVA.org:uu-403856" > Cardiac left ventri...
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000 | 04491naa a2200517 4500 | |
001 | oai:DiVA.org:uu-403856 | |
003 | SwePub | |
008 | 200205s2020 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:144017366 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4038562 URI |
024 | 7 | a https://doi.org/10.1016/j.schres.2019.12.0422 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1440173662 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Andreou, Dimitriosu Karolinska Institutet4 aut |
245 | 1 0 | a Cardiac left ventricular ejection fraction in men and women with schizophrenia on long-term antipsychotic treatment |
264 | 1 | b Elsevier BV,c 2020 |
338 | a electronic2 rdacarrier | |
520 | a Patients with schizophrenia exhibit a higher cardiovascular mortality compared to the general population which has been attributed to life-style factors, genetic susceptibility and antipsychotic medication. Recent echocardiographic studies have pointed to an association between clozapine treatment and reduced left ventricular ejection fraction (LVEF), a measure that has been inversely associated with adverse outcomes including all-cause mortality. Cardiovascular magnetic resonance (CMR) is considered the reference method for LVEF measurement. The aim of the present study was to investigate the LVEF in patients with schizophrenia on long-term treatment with antipsychotics and healthy controls. Twenty-nine adult patients with schizophrenia on long-term medication with antipsychotics and 27 age-, sex- and body mass index-matched healthy controls (mean ages 44 and 45 years, respectively) were recruited from outpatient psychiatric clinics in Uppsala, Sweden. The participants were interviewed and underwent physical examination, biochemical analyses, electrocardiogram and CMR. Men with schizophrenia on long-term antipsychotic treatment showed significantly lower LVEF than controls (p = 0.0076), whereas no such difference was evident among women (p = 0.44). Specifically, clozapine-treated male patients had 10.6% lower LVEF than male controls (p = 0.0064), whereas the LVEF was 5.5% below that of controls among male patients treated with non-clozapine antipsychotics (p = 0.047). Among medicated men with schizophrenia, we found significantly lower LVEF compared to healthy individuals, suggesting the need of routine cardiac monitoring in this patient group. This is the first study showing a significant negative association between treatment with non-clozapine antipsychotics and LVEF. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
653 | a Antipsychotics | |
653 | a Cardiovascular magnetic resonance | |
653 | a Clozapine | |
653 | a Left ventricular ejection fraction | |
653 | a Schizophrenia | |
700 | 1 | a Saetre, Peter4 aut |
700 | 1 | a Milesson Fors, Björnu Uppsala universitet,Ekselius: Psykiatri4 aut0 (Swepub:uu)bjormile |
700 | 1 | a Nilsson, Björn Mikaelu Uppsala universitet,Ekselius: Psykiatri4 aut0 (Swepub:uu)bjornilss |
700 | 1 | a Kullberg, Joel,d 1979-u Uppsala universitet,Radiologi4 aut0 (Swepub:uu)jokul377 |
700 | 1 | a Jönsson, Erik Gunnaru Karolinska Institutet4 aut |
700 | 1 | a Ebeling Barbier, Charlotteu Uppsala universitet,Radiologi4 aut0 (Swepub:uu)chebe226 |
700 | 1 | a Agartz, Ingridu Karolinska Institutet4 aut |
710 | 2 | a Karolinska Institutetb Ekselius: Psykiatri4 org |
773 | 0 | t Schizophrenia Researchd : Elsevier BVg 218, s. 226-232q 218<226-232x 0920-9964x 1573-2509 |
856 | 4 | u https://doi.org/10.1016/j.schres.2019.12.042y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1391707/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://doi.org/10.1016/j.schres.2019.12.042 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-403856 |
856 | 4 8 | u https://doi.org/10.1016/j.schres.2019.12.042 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:144017366 |
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