Search: onr:"swepub:oai:DiVA.org:uu-404487" >
A 6-month randomize...
A 6-month randomized, double-blind, placebo-controlled trial of weekly exenatide in adolescents with obesity
-
Weghuber, D. (author)
-
- Forslund, Anders, 1961- (author)
- Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa,Children Obesity Clinic, Uppsala University Hospital
-
- Ahlström, Håkan, 1953- (author)
- Uppsala universitet,Radiologi,Antaros Medical, Mölndal
-
show more...
-
- Alderborn, Anders (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
-
Bergström, K. (author)
-
Brunner, S. (author)
-
Cadamuro, J. (author)
-
- Ciba, Iris (author)
- Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa,Children Obesity Clinic, Uppsala University Hospital
-
- Dahlbom, Marie (author)
- Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa,Children Obesity Clinic, Uppsala University Hospital
-
Heu, V. (author)
-
Hofmann, J. (author)
-
- Kristinsson, Hjalti (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
-
- Kullberg, Joel, 1979- (author)
- Uppsala universitet,Radiologi,Antaros Medical, Mölndal
-
Ladinger, A. (author)
-
Lagler, F. B. (author)
-
Lidström, M. (author)
-
- Manell, Hannes (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Institutionen för medicinsk cellbiologi
-
Meirik, M. (author)
-
Mörwald, K. (author)
-
Roomp, K. (author)
-
Schneider, R. (author)
-
Vilén, H. (author)
-
Widhalm, K. (author)
-
Zsoldos, F. (author)
-
- Bergsten, Peter (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Pediatrisk inflammations- och metabolismforskning samt barnhälsa,Children Obesity Clinic, Uppsala University Hospital
-
show less...
-
(creator_code:org_t)
- 2020
- 2020
- English.
-
In: Pediatric Obesity. - 2047-6302 .- 2047-6310. ; 15:7
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://uu.diva-port... (primary) (Raw object)
-
https://onlinelibrar...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- BACKGROUND: Pharmacological treatment options for adolescents with obesity are very limited. Glucagon-like-peptide-1 (GLP-1) receptor agonist could be a treatment option for adolescent obesity.OBJECTIVE: To investigate the effect of exenatide extended release on body mass index (BMI)-SDS as primary outcome, and glucose metabolism, cardiometabolic risk factors, liver steatosis, and other BMI metrics as secondary outcomes, and its safety and tolerability in adolescents with obesity.METHODS: Six-month, randomized, double-blinded, parallel, placebo-controlled clinical trial in patients (n = 44, 10-18 years, females n = 22) with BMI-SDS > 2.0 or age-adapted-BMI > 30 kg/m2 according to WHO were included. Patients received lifestyle intervention and were randomized to exenatide extended release 2 mg (n = 22) or placebo (n = 22) subcutaneous injections given once weekly. Oral glucose tolerance tests (OGTT) were conducted at the beginning and end of the intervention.RESULTS: Exenatide reduced (P < .05) BMI-SDS (-0.09; -0.18, 0.00), % BMI 95th percentile (-2.9%; -5.4, -0.3), weight (-3 kg; -5.8, -0.1), waist circumference (-3.2 cm; -5.8, -0.7), subcutaneous adipose tissue (-552 cm3 ; -989, -114), 2-hour-glucose during OGTT (-15.3 mg/dL; -27.5, -3.1), total cholesterol (11.6 mg/dL; -21.7, -1.5), and BMI (-0.83 kg/m2 ; -1.68, 0.01) without significant change in liver fat content (-1.36; -3.12, 0.4; P = .06) in comparison to placebo. Safety and tolerability profiles were comparable to placebo with the exception of mild adverse events being more frequent in exenatide-treated patients.CONCLUSIONS: Treatment of adolescents with severe obesity with extended-release exenatide is generally well tolerated and leads to a modest reduction in BMI metrics and improvement in glucose tolerance and cholesterol. The study indicates that the treatment provides additional beneficial effects beyond BMI reduction for the patient group.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Body mass index
- GLP-1 receptor agonist
- exenatide
- glucose metabolism
- liver steatosis
- metabolic syndrome
- pediatric obesity
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Weghuber, D.
-
Forslund, Anders ...
-
Ahlström, Håkan, ...
-
Alderborn, Ander ...
-
Bergström, K.
-
Brunner, S.
-
show more...
-
Cadamuro, J.
-
Ciba, Iris
-
Dahlbom, Marie
-
Heu, V.
-
Hofmann, J.
-
Kristinsson, Hja ...
-
Kullberg, Joel, ...
-
Ladinger, A.
-
Lagler, F. B.
-
Lidström, M.
-
Manell, Hannes
-
Meirik, M.
-
Mörwald, K.
-
Roomp, K.
-
Schneider, R.
-
Vilén, H.
-
Widhalm, K.
-
Zsoldos, F.
-
Bergsten, Peter
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Pediatrics
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Endocrinology an ...
- Articles in the publication
-
Pediatric Obesit ...
- By the university
-
Uppsala University