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Evaluation of Arter...
Evaluation of Arterial Spin Labeling MRI : Comparison with 15O-Water PET on an Integrated PET/MR Scanner
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- Fahlström, Markus (author)
- Uppsala universitet,Radiologi
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- Appel, Lieuwe (author)
- Uppsala universitet,Radiologi
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- Kumlien, Eva (author)
- Uppsala universitet,Landtblom: Neurovetenskap
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- Danfors, Torsten, 1964- (author)
- Uppsala universitet,Radiologi
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- Engström, Mathias (author)
- GE Healthcare, Applied Science Laboratory
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- Wikström, Johan, 1964- (author)
- Uppsala universitet,Radiologi
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- Antoni, Gunnar (author)
- Uppsala universitet,Preparativ läkemedelskemi
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- Larsson, Elna-Marie (author)
- Uppsala universitet,Radiologi
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- Lubberink, Mark (author)
- Uppsala universitet,Radiologi
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(creator_code:org_t)
- 2021-05-01
- 2021
- English.
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In: Diagnostics (Basel). - : MDPI. - 2075-4418. ; 11:5
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Abstract
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- Cerebral blood flow (CBF) measurements are of high clinical value and can be acquired non-invasively with no radiation exposure using pseudo-continuous arterial spin labeling (ASL). The aim of this study was to evaluate accordance in resting state CBF between ASL (CBFASL) and 15O-water positron emission tomography (PET) (CBFPET) acquired simultaneously on an integrated 3T PET/MR system. The data comprised ASL and dynamic 15O-water PET data with arterial blood sampling of eighteen subjects (eight patients with focal epilepsy and ten healthy controls, age 21 to 61 years). 15O-water PET parametric CBF images were generated using a basis function implementation of the single tissue compartment model. Cortical and subcortical regions were automatically segmented using Freesurfer. Average CBFASL and CBFPET in grey matter were 60 ± 20 and 75 ± 22 mL/100 g/min respectively, with a relatively high correlation (r = 0.78, p < 0.001). Bland-Altman analysis revealed poor agreement (bias = −15 mL/100 g/min, lower and upper limits of agreements = −16 and 45 mL/100 g/min, respectively) with a negative relationship. Accounting for the negative relationship, the width of the limits of agreement could be narrowed from 61 mL/100 g/min to 35 mL/100 g/min using regression-based limits of agreements. Although a high correlation between CBFASL and CBFPET was found, the agreement in absolute CBF values was not sufficient for ASL to be used interchangeably with 15O-water PET.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Keyword
- ASL
- CBF
- PET/MR
- validation
- 15O-water
Publication and Content Type
- ref (subject category)
- art (subject category)
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Fahlström, Marku ...
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Appel, Lieuwe
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Kumlien, Eva
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Danfors, Torsten ...
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Engström, Mathia ...
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Wikström, Johan, ...
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Antoni, Gunnar
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Larsson, Elna-Ma ...
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Lubberink, Mark
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Radiology Nuclea ...
- Articles in the publication
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Diagnostics (Bas ...
- By the university
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Uppsala University