Gains of Chromosome 1p and 15q are Associated with Poor Survival After Cytoreductive Surgery and HIPEC for Treating Colorectal Peritoneal Metastases

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: onr:"swepub:oai:DiVA.org:uu-404693" > Gains of Chromosome...

1 of 1
Previous record
Next record
To hitlist

Details
MARC

Enblad, MalinUppsala universitet,Kolorektalkirurgi (author)

Gains of Chromosome 1p and 15q are Associated with Poor Survival After Cytoreductive Surgery and HIPEC for Treating Colorectal Peritoneal Metastases

Article/chapterEnglish2019

Publisher, publication year, extent ...

2019-10-16
Springer Nature,2019
electronicrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:uu-404693
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-404693URI
https://doi.org/10.1245/s10434-019-07923-6DOI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Purpose: Genetic alterations in colorectal peritoneal metastases (PM) are largely unknown. This study was designed to analyze whole-genome copy number alterations (CNA) in colorectal PM and to identify alterations associated with prognosis after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC)Methods: All patients with PM, originating from a colorectal adenocarcinoma, who were treated with CRS and HIPEC in Uppsala Sweden, between 2004 and 2015, were included (n = 114). DNA derived from formalin-fixed paraffin-embedded (FFPE) specimens were analyzed for CNA using molecular inversion probe arrays.Results: There were extensive but varying degrees of CNA, ranging from minimal CNA to total aneuploidy. In particular, gain of parts of chromosome 1p and major parts of 15q were associated with poor survival. A combination of gains of 1p and 15q was associated with poor survival, also after adjustment for differences in peritoneal cancer index and completeness of cytoreduction score [hazard ratio (HR) 5.96; 95% confidence interval (CI) 2.19-16.18]. These patients had a mean copy number (CN) of 3.19 compared with 2.24 in patients without gains. Complete CN analysis was performed in 53 patients. Analysis was unsuccessful for the remaining patients due to insufficient amounts of DNA and signals caused by interstitial components and normal cells. There was no difference in survival between patients with successful and unsuccessful CN analysis.Conclusions: This study shows that gains of parts of chromosome 1p and of major parts of chromosome 15q were significantly associated with poor survival after CRS and HIPEC, which could represent future prognostic biomarkers.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kirurgi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Surgery hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng

Added entries (persons, corporate bodies, meetings, titles ...)

Graf, WilhelmUppsala universitet,Kolorektalkirurgi(Swepub:uu)wilhgraf (author)
Terman, AlexeiUppsala universitet,Klinisk och experimentell patologi (author)
Pucholt, PascalUppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)paspu920 (author)
Viklund, BjörnUppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för medicinska vetenskaper(Swepub:uu)bjovi487 (author)
Isaksson, AndersUppsala universitet,Institutionen för medicinska vetenskaper,Science for Life Laboratory, SciLifeLab(Swepub:uu)andeisak (author)
Birgisson, HelgiUppsala universitet,Kolorektalkirurgi(Swepub:uu)hebir255 (author)
Uppsala universitetKolorektalkirurgi (creator_code:org_t)

Related titles

In:Annals of Surgical Oncology: Springer Nature26, s. 4835-48421068-92651534-4681

Internet link

Find in a library

Annals of Surgical Oncology (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Enblad, Malin; Graf, Wilhelm; Terman, Alexei; Pucholt, Pascal; Viklund, Björn; Isaksson, Anders; show more...; Birgisson, Helgi; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Surgery

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

Articles in the publication: Annals of Surgic ...

By the university: Uppsala University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se