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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04255naa a2200421 4500 | |
| 001 | oai:DiVA.org:uu-404693 | |
| 003 | SwePub | |
| 008 | 200227s2019 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4046932 URI |
| 024 | 7 | a https://doi.org/10.1245/s10434-019-07923-62 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Enblad, Malinu Uppsala universitet,Kolorektalkirurgi4 aut0 (Swepub:uu)malen817 |
| 245 | 1 0 | a Gains of Chromosome 1p and 15q are Associated with Poor Survival After Cytoreductive Surgery and HIPEC for Treating Colorectal Peritoneal Metastases |
| 264 | c 2019-10-16 | |
| 264 | 1 | b Springer Nature,c 2019 |
| 338 | a electronic2 rdacarrier | |
| 520 | a Purpose: Genetic alterations in colorectal peritoneal metastases (PM) are largely unknown. This study was designed to analyze whole-genome copy number alterations (CNA) in colorectal PM and to identify alterations associated with prognosis after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC)Methods: All patients with PM, originating from a colorectal adenocarcinoma, who were treated with CRS and HIPEC in Uppsala Sweden, between 2004 and 2015, were included (n = 114). DNA derived from formalin-fixed paraffin-embedded (FFPE) specimens were analyzed for CNA using molecular inversion probe arrays.Results: There were extensive but varying degrees of CNA, ranging from minimal CNA to total aneuploidy. In particular, gain of parts of chromosome 1p and major parts of 15q were associated with poor survival. A combination of gains of 1p and 15q was associated with poor survival, also after adjustment for differences in peritoneal cancer index and completeness of cytoreduction score [hazard ratio (HR) 5.96; 95% confidence interval (CI) 2.19-16.18]. These patients had a mean copy number (CN) of 3.19 compared with 2.24 in patients without gains. Complete CN analysis was performed in 53 patients. Analysis was unsuccessful for the remaining patients due to insufficient amounts of DNA and signals caused by interstitial components and normal cells. There was no difference in survival between patients with successful and unsuccessful CN analysis.Conclusions: This study shows that gains of parts of chromosome 1p and of major parts of chromosome 15q were significantly associated with poor survival after CRS and HIPEC, which could represent future prognostic biomarkers. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 700 | 1 | a Graf, Wilhelmu Uppsala universitet,Kolorektalkirurgi4 aut0 (Swepub:uu)wilhgraf |
| 700 | 1 | a Terman, Alexeiu Uppsala universitet,Klinisk och experimentell patologi4 aut |
| 700 | 1 | a Pucholt, Pascalu Uppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)paspu920 |
| 700 | 1 | a Viklund, Björnu Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för medicinska vetenskaper4 aut0 (Swepub:uu)bjovi487 |
| 700 | 1 | a Isaksson, Andersu Uppsala universitet,Institutionen för medicinska vetenskaper,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)andeisak |
| 700 | 1 | a Birgisson, Helgiu Uppsala universitet,Kolorektalkirurgi4 aut0 (Swepub:uu)hebir255 |
| 710 | 2 | a Uppsala universitetb Kolorektalkirurgi4 org |
| 773 | 0 | t Annals of Surgical Oncologyd : Springer Natureg 26, s. 4835-4842q 26<4835-4842x 1068-9265x 1534-4681 |
| 856 | 4 | u https://doi.org/10.1245/s10434-019-07923-6y Fulltext |
| 856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1397475/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u https://link.springer.com/content/pdf/10.1245/s10434-019-07923-6.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-404693 |
| 856 | 4 8 | u https://doi.org/10.1245/s10434-019-07923-6 |
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