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Synchrotron Radiati...
Synchrotron Radiation-Based Reconstruction of the Human Spiral Ganglion : Implications for Cochlear Implantation
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- Li, Hao, 1984- (author)
- Uppsala universitet,Öron-, näs- och halssjukdomar
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- Schart-Moren, Nadine (author)
- Uppsala universitet,Öron-, näs- och halssjukdomar
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- Rohani, Seyed Alireza (author)
- Western Univ London, Dept Otolaryngol Head & Neck Surg, London, ON, Canada
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- Ladak, Hanif M. (author)
- Western Univ London, Dept Otolaryngol Head & Neck Surg, London, ON, Canada;Western Univ London, Dept Med Biophys, London, ON, Canada;Western Univ London, Dept Elect & Comp Engn, London, ON, Canada
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- Rask-Andersen, Helge (author)
- Uppsala universitet,Öron-, näs- och halssjukdomar
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- Agrawal, Sumit (author)
- Western Univ London, Dept Otolaryngol Head & Neck Surg, London, ON, Canada
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(creator_code:org_t)
- LIPPINCOTT WILLIAMS & WILKINS, 2020
- 2020
- English.
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In: Ear and Hearing. - : LIPPINCOTT WILLIAMS & WILKINS. - 0196-0202 .- 1538-4667. ; 41:1, s. 173-181
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Objective: To three-dimensionally reconstruct Rosenthal's canal (RC) housing the human spiral ganglion (SG) using synchrotron radiation phase-contrast imaging (SR-PCI). Straight cochlear implant electrode arrays were inserted to better comprehend the electro-cochlear interface in cochlear implantation (CI).Design: SR-PCI was used to reconstruct the human cochlea with and without cadaveric CI. Twenty-eight cochleae were volume rendered, of which 12 underwent cadaveric CI with a straight electrode via the round window (RW). Data were input into the 3D Slicer software program and anatomical structures were modeled using a threshold paint tool.Results: The human RC and SG were reproduced three-dimensionally with artefact-free imaging of electrode arrays. The anatomy of the SG and its relationship to the sensory organ (Corti) and soft and bony structures were assessed.Conclusions: SR-PCI and computer-based three-dimensional reconstructions demonstrated the relationships among implanted electrodes, angular insertion depths, and the SG for the first time in intact, unstained, and nondecalcified specimens. This information can be used to assess stimulation strategies and future electrode designs, as well as create place-frequency maps of the SG for optimal stimulation strategies of the human auditory nerve in CI.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Cochlea
- Human
- Rosenthal's canal
- Spiral ganglion
- Synchrotron imaging
Publication and Content Type
- ref (subject category)
- art (subject category)
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