Exploring the Benefit of 2-Methylbutyric Acid in Patients Undergoing Hemodialysis Using a Cardiovascular Proteomics Approach

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Exploring the Benefit of 2-Methylbutyric Acid in Patients Undergoing Hemodialysis Using a Cardiovascular Proteomics Approach

Wu, Ping-Hsun (author): Uppsala universitet,Endokrinologi och mineralmetabolism,Kaohsiung Med Univ, Grad Inst Clin Med, Coll Med, Kaohsiung 80708, Taiwan;Kaohsiung Med Univ, Fac Med, Coll Med, Kaohsiung 80708, Taiwan;Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung 80708, Taiwan

Chiu, Yi-Wen (author): Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung 80708, Taiwan;Kaohsiung Med Univ, Fac Renal Care, Coll Med, Kaohsiung 80708, Taiwan

Zou, Hsin-Bai (author): Natl Taiwan Univ, Dept Chem, Taipei 10617, Taiwan

Hsu, Cheng-Chih (author): Natl Taiwan Univ, Dept Chem, Taipei 10617, Taiwan

Lee, Su-Chu (author): Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung 80708, Taiwan

Yi-Ting, Lin (author): Uppsala universitet,Kardiologi,Kaohsiung Med Univ, Grad Inst Clin Med, Coll Med, Kaohsiung 80708, Taiwan;Kaohsiung Med Univ, Fac Med, Coll Med, Kaohsiung 80708, Taiwan;Kaohsiung Med Univ Hosp, Dept Family Med, Kaohsiung 80708, Taiwan

Tsai, Yi-Chun (author): Kaohsiung Med Univ, Fac Med, Coll Med, Kaohsiung 80708, Taiwan;Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung 80708, Taiwan;Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Div Gen Med, Kaohsiung 80708, Taiwan

Kuo, Mei-Chuan (author): Kaohsiung Med Univ, Fac Med, Coll Med, Kaohsiung 80708, Taiwan;Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung 80708, Taiwan;Kaohsiung Med Univ, Fac Renal Care, Coll Med, Kaohsiung 80708, Taiwan

Hwang, Shang-Jyh (author): Kaohsiung Med Univ, Fac Med, Coll Med, Kaohsiung 80708, Taiwan;Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung 80708, Taiwan;Kaohsiung Med Univ, Fac Renal Care, Coll Med, Kaohsiung 80708, Taiwan

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2019-12-12
2019
English.
In: Nutrients. - : MDPI. - 2072-6643. ; 11:12

Related links:: https://doi.org/10.3...; show more...; https://uu.diva-port... (primary) (Raw object); https://www.mdpi.com...; https://urn.kb.se/re...; https://doi.org/10.3...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Short-chain fatty acids (SCFAs) can reduce pro-inflammatory parameters and oxidative stress, providing potential cardiovascular (CV) benefits. Although some evidence links SCFAs with host metabolic health via several biological mechanisms, the role of SCFA on CV disease in patients with kidney disease remains unclear. Herein, we investigate the association between a SCFA, 2-methylbutyric acid, and target CV proteomics to explore the potential pathophysiology of SCFA-related CV benefit in patients with kidney disease. Circulating 2-methylbutyric acid was quantified by high-performance liquid chromatography and 181 CV proteins by a proximity extension assay in 163 patients undergoing hemodialysis (HD). The associations between 2-methylbutyric acid and CV proteins were evaluated using linear regression analysis with age and gender, and multiple testing adjustment. The selected CV protein in the discovery phase was further confirmed in multivariable-adjusted models and evaluated by continuous scale association. The mean value of circulating 2-methylbutyric acid was 0.22 +/- 0.02 mu m which was negatively associated with bone morphogenetic protein 6 (BMP-6) according to the false discovery rate (FDR) multiple testing adjustment method. The 2-methylbutyric acid level remained negatively associated with BMP-6 (beta coefficient -1.00, 95% confidence interval -1.45 to -0.55, p < 0.001) after controlling for other CV risk factors in multivariable models. The cubic spline curve demonstrated a linear relationship. In conclusion, circulating 2-methylbutyric acid level was negatively associated with BMP-6, suggesting that this pathway maybe involved in vascular health in patients undergoing HD. However, further in vitro work is still needed to validate the translation of the mechanistic pathways.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)

Keyword

short-chain fatty acids
2-methylbutyric acid
target proteomics
bone morphogenetic protein 6
hemodialysis
end-stage renal disease

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art (subject category)

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By the author/editor: Wu, Ping-Hsun; Chiu, Yi-Wen; Zou, Hsin-Bai; Hsu, Cheng-Chih; Lee, Su-Chu; Yi-Ting, Lin; show more...; Tsai, Yi-Chun; Kuo, Mei-Chuan; Hwang, Shang-Jyh; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Nutrition and Di ...

Articles in the publication: Nutrients

By the university: Uppsala University

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