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Cost-effectiveness ...
Cost-effectiveness analysis of repeated self-sampling for HPV testing in primary cervical screening: a randomized study
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- Aarnio, Riina, 1971- (author)
- Uppsala universitet,Reproduktionsbiologi
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- Östensson, Ellinor (author)
- Karolinska Institutet
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- Olovsson, Matts, 1958- (author)
- Uppsala universitet,Reproduktionsbiologi
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- Gustavsson, Inger M. (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik
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- Gyllensten, Ulf B. (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik
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(creator_code:org_t)
- 2020-07-13
- 2020
- English.
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In: BMC Cancer. - : Springer Science and Business Media LLC. - 1471-2407. ; 20:1
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https://bmccancer.bi...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- BackgroundHuman papillomavirus (HPV) testing is recommended in primary cervical screening to improve cancer prevention. An advantage of HPV testing is that it can be performed on self-samples, which could increase population coverage and result in a more efficient strategy to identify women at risk of developing cervical cancer. Our objective was to assess whether repeated self-sampling for HPV testing is cost-effective in comparison with Pap smear cytology for detection of cervical intraepithelial neoplasia grade 2 or more (CIN2+) in increasing participation rate in primary cervical screening.MethodsA cost-effectiveness analysis (CEA) was performed on data from a previously published randomized clinical study including 36 390 women aged 30–49 years. Participants were randomized either to perform repeated self-sampling of vaginal fluid for HPV testing (n = 17 997, HPV self-sampling arm) or to midwife-collected Pap smears for cytological analysis (n = 18 393, Pap smear arm).ResultsSelf-sampling for HPV testing led to 1633 more screened women and 107 more histologically diagnosed CIN2+ at a lower cost vs. midwife-collected Pap smears (€ 228 642 vs. € 781 139). ConclusionsThis study projected that repeated self-sampling for HPV testing increased participation and detection of CIN2+ at a lower cost than midwife-collected Pap smears in primary cervical screening. Offering women a home-based self-sampling may therefore be a more cost-effective alternative than clinic-based screening.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- Self-sampling
- HPV testing
- primary cervical screening
- cost-effectiveness
- CIN2
- precancerous lesion
- cervical cancer
- Obstetrik och gynekologi
- Obstetrics and Gynaecology
Publication and Content Type
- vet (subject category)
- art (subject category)
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