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Secondary ossificat...
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Xie, MengDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
(author)
Secondary ossification center induces and protects growth plate structure
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LIBRIS-ID:oai:DiVA.org:uu-405966
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-405966URI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Growth plate and articular cartilage constitute a single anatomical entity, but later separate into two distinct structures by the formation of secondary ossification center (SOC). The reason for such spatial separation remains unknown. Here, we demonstrate that evolutionarily SOC first appears in amniotes. Mathematical modelling reveals that SOC reduces mechanical stress within the growth plate. Analysis of mammals with specialized extremities reveals that SOC size correlates with the extent of mechanical demands. Ex and in vivo experiments demonstrate that SOC allows epiphyseal chondrocytes to withstand a several-fold higher load before activation of the YAP-p73 signalling pathway and caspase-dependent apoptosis, with hypertrophic chondrocytes being the most load-sensitive cells. Atomic force microscopy shows that hypertrophic chondrocytes are the least mechanically stiff cells within the growth plate. Altogether, these findings suggest that SOC is evolved to protect epiphyseal chondrocytes, especially the hypertrophic chondrocytes, from the high mechanical stress encountered in the terrestrial environment.
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Gol'din, PavelDepartment of Evolutionary Morphology, Schmalhausen Institute of Zoology of NAS of Ukraine, Ukraine
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Nele Herdina, AnnaDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
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Estefa, Jordi,1987-Uppsala universitet,Institutionen för organismbiologi(Swepub:uu)jores915
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Medvedeva, EkaterinaDivision of Anatomy, MIC, Medical University of Vienna, Austria,Institute for Regenerative Medicine, Sechenov University, Russia
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Li, LeiDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
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Newton, PhillipDepartment of Women’s and Children’s Health, Astrid Lindgren Children’s Hospital, Karolinska University Hospital, Sweden,Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
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Kotova, SvetlanaSemenov Institute of Chemical Physics, Russia,Institute for Regenerative Medicine, Sechenov University, Russia
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Shavkuta, BorisInstitute of Photonic Technologies, Research center "Crystallography and Photonics", Russia,Institute for Regenerative Medicine, Sechenov University, Russia
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Saxena, AdityaDivision of Biological Sciences, University of California San Diego, USA
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Shumate, LaurenEndocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, U.S.A.
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Metscher, BrianDepartment of Theoretical Biology, University of Vienna, Austria
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Grossschmidt, KarlBone and Biomaterials Research, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria
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Nishimori, ShigekiEndocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, U.S.A.
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Akovantseva, AnastasiaInstitute of Photonic Technologies, Research center "Crystallography and Photonics", Russia,Institute for Regenerative Medicine, Sechenov University, Russia
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Linares Arregui, IreneDepartment of Solid Mechanics, KTH Royal Institute of Technology, Stockholm, Sweden
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Tafforeau, PaulEuropean Synchrotron Radiation Facility, Grenoble, France
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Fried, KajDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden
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Carlström, MattiasDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
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Simon, AndrasDepartment of Cell and Molecular Biology, Centre of Developmental Biology for Regenerative Medicine, Karolinska Institute, Stockholm, Sweden
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Gasser, ChristianDepartment of Solid Mechanics, KTH Royal Institute of Technology, Stockholm, Sweden
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Kronenberg, HenryEndocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, U.S.A.
(author)
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Bastepe, MuratEndocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, U.S.A.
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Cooper, KimberlyDivision of Biological Sciences, University of California San Diego, USA
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Timashev, PeterSemenov Institute of Chemical Physics, Russia,Institute for Regenerative Medicine, Sechenov University, Russia
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Sanchez, SophieUppsala universitet,Institutionen för organismbiologi
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Adameyko, IgorDepartment of Molecular Neurosciences, Medical University of Vienna, Austria,Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
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Eriksson, AndersDepartment of Mechanics, KTH Royal Institute of Technology, Stockholm, Sweden
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Chagin, AndreiInstitute for Regenerative Medicine, Sechenov University, Russia,Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
(author)
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Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, SwedenDepartment of Evolutionary Morphology, Schmalhausen Institute of Zoology of NAS of Ukraine, Ukraine
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Xie, Meng
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Gol'din, Pavel
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Nele Herdina, An ...
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Estefa, Jordi, 1 ...
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Medvedeva, Ekate ...
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Li, Lei
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Newton, Phillip
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Kotova, Svetlana
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Shavkuta, Boris
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Saxena, Aditya
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Shumate, Lauren
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Metscher, Brian
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Grossschmidt, Ka ...
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Nishimori, Shige ...
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Akovantseva, Ana ...
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Linares Arregui, ...
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Tafforeau, Paul
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Fried, Kaj
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Carlström, Matti ...
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Simon, Andras
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Gasser, Christia ...
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Bastepe, Murat
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Cooper, Kimberly
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Timashev, Peter
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Adameyko, Igor
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Eriksson, Anders
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Chagin, Andrei
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