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The triglyceride-gl...
The triglyceride-glucose index as a measure of insulin resistance and risk of obesity-related cancers
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- Fritz, Josef (author)
- Medical University of Innsbruck
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- Bjørge, Tone (author)
- Cancer Registry of Norway, Institute of Population-Based Cancer Research,University of Bergen
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- Nagel, Gabriele (author)
- University of Ulm
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- Manjer, Jonas (author)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital
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- Engeland, Anders (author)
- Norwegian Institute of Public Health,University of Bergen
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- Häggström, Christel (author)
- Uppsala University,Umeå University,Umeå universitet,Uppsala universitet,Urologkirurgi,Department of Biobank Research, Umeå University; Department of Public Health and Clinical Medicine, Nutritional Research, Umeå University,Enheten för biobanksforskning,Näringsforskning,Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
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- Concin, Hans (author)
- Agency for Preventive and Social Medicine Vorarlberg
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- Teleka, Stanley (author)
- Lund University,Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Biomarkörer och Epi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Biomarkers and epidemiology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Tretli, Steinar (author)
- Cancer Registry of Norway, Institute of Population-Based Cancer Research
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- Gylling, Björn, 1978- (author)
- Umeå University,Umeå universitet,Patologi
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- Lang, Alois (author)
- Agency for Preventive and Social Medicine Vorarlberg
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- Stattin, Pär (author)
- Uppsala University,Umeå universitet,Uppsala universitet,Urologkirurgi,Urologi och andrologi
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- Stocks, Tanja (author)
- Lund University,Lunds universitet,Umeå universitet,Urologi och andrologi,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Biomarkörer och Epi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Biomarkers and epidemiology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Ulmer, Hanno (author)
- Medical University of Innsbruck
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(creator_code:org_t)
- 2019-04-03
- 2020
- English.
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In: International Journal of Epidemiology. - : Oxford University Press (OUP). - 0300-5771 .- 1464-3685. ; 49:1, s. 193-204
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Abstract
Subject headings
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- BACKGROUND: The role of insulin resistance as a mediator in the association of body mass index (BMI) with site-specific cancer risk has, to our knowledge, never been systematically quantified.METHODS: Altogether 510 471 individuals from six European cohorts, with a mean age of 43.1 years, were included. We used the triglyceride glucose product (TyG index) as a surrogate measure for insulin resistance. We fitted Cox models, adjusted for relevant confounders, to investigate associations of TyG index with 10 common obesity-related cancers, and quantified the proportion of the effect of BMI mediated through TyG index on the log-transformed hazard ratio (HR) scale.RESULTS: During a median follow-up of 17.2 years, 16 052 individuals developed obesity-related cancers. TyG index was associated with the risk of cancers of the kidney HR per one standard deviation increase 1.13, 95% confidence interval: 1.07 to 1.20], liver (1.13, 1.04 to 1.23), pancreas (1.12, 1.06 to 1.19), colon (1.07, 1.03 to 1.10) and rectum (1.09, 1.04 to 1.14). Substantial proportions of the effect of BMI were mediated by TyG index for cancers of the pancreas (42%), rectum (34%) and colon (20%); smaller proportions for kidney (15%) and liver (11%). Little or no mediation was observed for breast (postmenopausal), endometrial and ovarian cancer. Results were similar for males and females, except for pancreatic cancer where the proportions mediated were 20% and 91%, respectively.CONCLUSIONS: The TyG index was associated with increased risk of cancers of the digestive system and substantially mediated the effect of BMI, suggesting that insulin resistance plays a promoting role in the pathogenesis of gastrointestinal cancers.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- Obesity
- cancer
- insulin resistance
- longitudinal study
- mediation analysis
- Cancer
- Insulin resistance
- Longitudinal study
- Mediation analysis
- Obesity
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Fritz, Josef
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Bjørge, Tone
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Nagel, Gabriele
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Manjer, Jonas
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Engeland, Anders
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Häggström, Chris ...
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show more...
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Concin, Hans
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Teleka, Stanley
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Tretli, Steinar
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Gylling, Björn, ...
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Lang, Alois
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Stattin, Pär
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Stocks, Tanja
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Ulmer, Hanno
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
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International Jo ...
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Uppsala University
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Umeå University
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Lund University