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  • Berglund, ErikKarolinska Institutet (author)

Clinical Significance of Alloantibodies in Hand Transplantation : A Multicenter Study

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • LIPPINCOTT WILLIAMS & WILKINS,2019
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-406474
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-406474URI
  • https://doi.org/10.1097/TP.0000000000002650DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:142821465URI

Supplementary language notes

  • Language:English
  • Summary in:English

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Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background. Donor-specific antibodies (DSAs) have a strong negative correlation with long-term survival in solid organ transplantation. Although the clinical significance of DSA and antibody-mediated rejection (AMR) in upper extremity transplantation (UET) remains to be established, a growing number of single-center reports indicate their presence and potential clinical impact. Methods. We present a multicenter study assessing the occurrence and significance of alloantibodies in UET in reference to immunological parameters and functional outcome. Results. Our study revealed a high prevalence and early development of de novo DSA and non-DSA (43%, the majority detected within the first 3 postoperative y). HLA class II mismatch correlated with antibody development, which in turn significantly correlated with the incidence of acute cellular rejection. Cellular rejections preceded antibody development in almost all cases. A strong correlation between DSA and graft survival or function cannot be statistically established at this early stage but a correlation with a lesser outcome seems to emerge. Conclusions. While the phenotype and true clinical effect of AMR remain to be better defined, the high prevalence of DSA and the correlation with acute rejection highlight the need for optimizing immunosuppression, close monitoring, and the relevance of an HLA class II match in UET recipients.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Andersen Ljungdahl, MetteKarolinska Inst, Karolinska Univ Hosp, Dept Transplantat Surg, Div Transplantat Surg,CLINTEC, Stockholm, Sweden (author)
  • Bogdanovic, DarkoKarolinska Inst, Karolinska Univ Hosp, Dept Transplantat Surg, Div Transplantat Surg,CLINTEC, Stockholm, Sweden (author)
  • Berglund, David,1984-Uppsala universitet,Klinisk immunologi(Swepub:uu)davbe892 (author)
  • Wadstroem, JonasKarolinska Inst, Karolinska Univ Hosp, Dept Transplantat Surg, Div Transplantat Surg,CLINTEC, Stockholm, Sweden (author)
  • Kowalski, JanJK Biostat AB, Stockholm, Sweden (author)
  • Brandacher, GeraldJohns Hopkins Univ, Sch Med, Dept Plast & Reconstruct Surg, Baltimore, MD USA (author)
  • Kaminska, DorotaWroclaw Med Univ, Dept Nephrol & Transplantat Med, Wroclaw, Poland (author)
  • Kaufman, Christina L.Christine M Kleinert Inst Hand & Microsurg, Louisville, KY USA (author)
  • Talbot, Simon G.Brigham & Womens Hosp, Div Plast Surg, 75 Francis St, Boston, MA 02115 USA (author)
  • Azari, KodiUniv Calif Los Angeles, David Geffen Sch Med, Dept Orthopaed Surg, Div Plast Surg, Los Angeles, CA 90095 USA (author)
  • Landin, LuisHosp Univ La Paz, Div Plast & Reconstruct Surg, IdiPaz, FIBHULP, Madrid, Spain (author)
  • Hoehnke, ChristophKlinikum Memmingen, Div Plast & Reconstruct Surg, Memmingen, Germany;Tech Univ Munich, Munich, Germany (author)
  • Dwyer, Karen M.Deakin Univ, Sch Med, Fac Hlth, Geelong, Vic, Australia (author)
  • Cavadas, Pedro C.Clin Cavadas, Plast & Reconstruct Surg Div, Valencia, Spain (author)
  • Thione, AlessandroClin Cavadas, Plast & Reconstruct Surg Div, Valencia, Spain (author)
  • Clarke, BrendanLeeds Gen Infirm, Dept Plast & Reconstruct Surg, Leeds, W Yorkshire, England (author)
  • Kay, SimonLeeds Gen Infirm, Dept Plast & Reconstruct Surg, Leeds, W Yorkshire, England (author)
  • Wilks, DanLeeds Gen Infirm, Dept Plast & Reconstruct Surg, Leeds, W Yorkshire, England (author)
  • Iyer, SubramaniaAmrita Inst Med Sci, Plast Reconstruct Surg, Kochi, Kerala, India (author)
  • Iglesias, MartinInst Nacl Ciencias Med & Nutr Salvador Zubiran, Mexico City, DF, Mexico (author)
  • Ozkan, OmerAkdeniz Univ, Fac Med, Dept Plast & Reconstruct Surg, Antalya, Turkey (author)
  • Ozkan, OzlenenAkdeniz Univ, Fac Med, Dept Plast & Reconstruct Surg, Antalya, Turkey (author)
  • Krapf, JohannaInnsbruck Med Univ, Dept Plast & Reconstruct Surg, Innsbruck, Austria (author)
  • Weissenbacher, AnnemarieMed Univ Innsbruck, Ctr Operat Med, Dept Visceral Transplant & Thorac Surg, Innsbruck, Austria;Univ Oxford, Churchill Hosp, Oxford Transplant Ctr, Nuffield Dept Surg Sci, Oxford, England (author)
  • Petruzzo, PalminaHop Edouard Herriot, HCL, Dept Transplantat, Lyon, France (author)
  • Schneeberger, StefanMed Univ Innsbruck, Ctr Operat Med, Dept Visceral Transplant & Thorac Surg, Innsbruck, Austria (author)
  • Karolinska InstitutetKarolinska Inst, Karolinska Univ Hosp, Dept Transplantat Surg, Div Transplantat Surg,CLINTEC, Stockholm, Sweden (creator_code:org_t)

Related titles

  • In:Transplantation: LIPPINCOTT WILLIAMS & WILKINS103:10, s. 2173-21820041-13371534-6080

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