SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:DiVA.org:uu-406474"
 

Search: onr:"swepub:oai:DiVA.org:uu-406474" > Clinical Significan...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006058naa a2200625 4500
001oai:DiVA.org:uu-406474
003SwePub
008200309s2019 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:142821465
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4064742 URI
0247 a https://doi.org/10.1097/TP.00000000000026502 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1428214652 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Berglund, Eriku Karolinska Institutet4 aut
2451 0a Clinical Significance of Alloantibodies in Hand Transplantation :b A Multicenter Study
264 1b LIPPINCOTT WILLIAMS & WILKINS,c 2019
338 a print2 rdacarrier
520 a Background. Donor-specific antibodies (DSAs) have a strong negative correlation with long-term survival in solid organ transplantation. Although the clinical significance of DSA and antibody-mediated rejection (AMR) in upper extremity transplantation (UET) remains to be established, a growing number of single-center reports indicate their presence and potential clinical impact. Methods. We present a multicenter study assessing the occurrence and significance of alloantibodies in UET in reference to immunological parameters and functional outcome. Results. Our study revealed a high prevalence and early development of de novo DSA and non-DSA (43%, the majority detected within the first 3 postoperative y). HLA class II mismatch correlated with antibody development, which in turn significantly correlated with the incidence of acute cellular rejection. Cellular rejections preceded antibody development in almost all cases. A strong correlation between DSA and graft survival or function cannot be statistically established at this early stage but a correlation with a lesser outcome seems to emerge. Conclusions. While the phenotype and true clinical effect of AMR remain to be better defined, the high prevalence of DSA and the correlation with acute rejection highlight the need for optimizing immunosuppression, close monitoring, and the relevance of an HLA class II match in UET recipients.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng
7001 a Andersen Ljungdahl, Metteu Karolinska Inst, Karolinska Univ Hosp, Dept Transplantat Surg, Div Transplantat Surg,CLINTEC, Stockholm, Sweden4 aut
7001 a Bogdanovic, Darkou Karolinska Inst, Karolinska Univ Hosp, Dept Transplantat Surg, Div Transplantat Surg,CLINTEC, Stockholm, Sweden4 aut
7001 a Berglund, David,d 1984-u Uppsala universitet,Klinisk immunologi4 aut0 (Swepub:uu)davbe892
7001 a Wadstroem, Jonasu Karolinska Inst, Karolinska Univ Hosp, Dept Transplantat Surg, Div Transplantat Surg,CLINTEC, Stockholm, Sweden4 aut
7001 a Kowalski, Janu JK Biostat AB, Stockholm, Sweden4 aut
7001 a Brandacher, Geraldu Johns Hopkins Univ, Sch Med, Dept Plast & Reconstruct Surg, Baltimore, MD USA4 aut
7001 a Kaminska, Dorotau Wroclaw Med Univ, Dept Nephrol & Transplantat Med, Wroclaw, Poland4 aut
7001 a Kaufman, Christina L.u Christine M Kleinert Inst Hand & Microsurg, Louisville, KY USA4 aut
7001 a Talbot, Simon G.u Brigham & Womens Hosp, Div Plast Surg, 75 Francis St, Boston, MA 02115 USA4 aut
7001 a Azari, Kodiu Univ Calif Los Angeles, David Geffen Sch Med, Dept Orthopaed Surg, Div Plast Surg, Los Angeles, CA 90095 USA4 aut
7001 a Landin, Luisu Hosp Univ La Paz, Div Plast & Reconstruct Surg, IdiPaz, FIBHULP, Madrid, Spain4 aut
7001 a Hoehnke, Christophu Klinikum Memmingen, Div Plast & Reconstruct Surg, Memmingen, Germany;Tech Univ Munich, Munich, Germany4 aut
7001 a Dwyer, Karen M.u Deakin Univ, Sch Med, Fac Hlth, Geelong, Vic, Australia4 aut
7001 a Cavadas, Pedro C.u Clin Cavadas, Plast & Reconstruct Surg Div, Valencia, Spain4 aut
7001 a Thione, Alessandrou Clin Cavadas, Plast & Reconstruct Surg Div, Valencia, Spain4 aut
7001 a Clarke, Brendanu Leeds Gen Infirm, Dept Plast & Reconstruct Surg, Leeds, W Yorkshire, England4 aut
7001 a Kay, Simonu Leeds Gen Infirm, Dept Plast & Reconstruct Surg, Leeds, W Yorkshire, England4 aut
7001 a Wilks, Danu Leeds Gen Infirm, Dept Plast & Reconstruct Surg, Leeds, W Yorkshire, England4 aut
7001 a Iyer, Subramaniau Amrita Inst Med Sci, Plast Reconstruct Surg, Kochi, Kerala, India4 aut
7001 a Iglesias, Martinu Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Mexico City, DF, Mexico4 aut
7001 a Ozkan, Omeru Akdeniz Univ, Fac Med, Dept Plast & Reconstruct Surg, Antalya, Turkey4 aut
7001 a Ozkan, Ozlenenu Akdeniz Univ, Fac Med, Dept Plast & Reconstruct Surg, Antalya, Turkey4 aut
7001 a Krapf, Johannau Innsbruck Med Univ, Dept Plast & Reconstruct Surg, Innsbruck, Austria4 aut
7001 a Weissenbacher, Annemarieu Med Univ Innsbruck, Ctr Operat Med, Dept Visceral Transplant & Thorac Surg, Innsbruck, Austria;Univ Oxford, Churchill Hosp, Oxford Transplant Ctr, Nuffield Dept Surg Sci, Oxford, England4 aut
7001 a Petruzzo, Palminau Hop Edouard Herriot, HCL, Dept Transplantat, Lyon, France4 aut
7001 a Schneeberger, Stefanu Med Univ Innsbruck, Ctr Operat Med, Dept Visceral Transplant & Thorac Surg, Innsbruck, Austria4 aut
7102 a Karolinska Institutetb Karolinska Inst, Karolinska Univ Hosp, Dept Transplantat Surg, Div Transplantat Surg,CLINTEC, Stockholm, Sweden4 org
7730 t Transplantationd : LIPPINCOTT WILLIAMS & WILKINSg 103:10, s. 2173-2182q 103:10<2173-2182x 0041-1337x 1534-6080
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-406474
8564 8u https://doi.org/10.1097/TP.0000000000002650
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:142821465

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view