onr:"swepub:oai:DiVA.org:uu-407643"
Search: onr:"swepub:oai:DiVA.org:uu-407643" > Falciparum malaria ...
- 1 of 1
- Previous record
- Next record
- To hitlist
Falciparum malaria from coastal Tanzania and Zanzibar remains highly connected despite effective control efforts on the archipelago
-
- Morgan, Andrew P. (author)
- Univ North Carolina Chapel Hill, Sch Med, Dept Med, Div Infect Dis, Chapel Hill, NC 27599 USA
-
- Brazeau, Nicholas F. (author)
- Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27599 USA
-
- Ngasala, Billy (author)
- Uppsala universitet,Internationell barnhälsa och nutrition,Muhimbili Univ Hlth & Allied Sci, Dept Parasitol & Med Entomol, Dar Es Salaam, Tanzania
- show more...
- show less...
- (creator_code:org_t)
- 2020-01-28
- 2020
- English.
- In: Malaria Journal. - : BMC. - 1475-2875. ; 19
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Background: Tanzania's Zanzibar archipelago has made significant gains in malaria control over the last decade and is a target for malaria elimination. Despite consistent implementation of effective tools since 2002, elimination has not been achieved. Importation of parasites from outside of the archipelago is thought to be an important cause of malaria's persistence, but this paradigm has not been studied using modern genetic tools.Methods: Whole-genome sequencing (WGS) was used to investigate the impact of importation, employing population genetic analyses of Plasmodium falciparum isolates from both the archipelago and mainland Tanzania. Ancestry, levels of genetic diversity and differentiation, patterns of relatedness, and patterns of selection between these two populations were assessed by leveraging recent advances in deconvolution of genomes from polyclonal malaria infections.Results: Significant decreases in the effective population sizes were inferred in both populations that coincide with a period of decreasing malaria transmission in Tanzania. Identity by descent analysis showed that parasites in the two populations shared long segments of their genomes, on the order of 5 cM, suggesting shared ancestry within the last 10 generations. Even with limited sampling, two of isolates between the mainland and Zanzibar were identified that are related at the expected level of half-siblings, consistent with recent importation.Conclusions: These findings suggest that importation plays an important role for malaria incidence on Zanzibar and demonstrate the value of genomic approaches for identifying corridors of parasite movement to the island.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- Plasmodium
- Malaria
- Population genetics
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Malaria Journal (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Morgan, Andrew P ...
- Brazeau, Nichola ...
- Ngasala, Billy
- Mhamilawa, Lwidi ...
- Denton, Madeline
- Msellem, Mwinyi
- show more...
- Morris, Ulrika
- Filer, Dayne L.
- Aydemir, Ozkan
- Bailey, Jeffrey ...
- Parr, Jonathan B ...
- Mårtensson, Andr ...
- Bjorkman, Anders
- Juliano, Jonatha ...
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Infectious Medic ...
- Articles in the publication
- Malaria Journal
- By the university
- Uppsala University
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
