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Selective in vivo m...
Selective in vivo molecular and cellular biocompatibility of black peppercorns by piperine-protein intrinsic atomic interaction with elicited oxidative stress and apoptosis in zebrafish eleuthero embryos
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- Patel, Paritosh (author)
- KIIT Univ, Sch Biotechnol, Bhubaneswar 751024, India
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- Panda, Pritam Kumar, PhD Student, 1991- (author)
- Uppsala universitet,Materialteori
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- Kumari, Puja (author)
- Vinoba Bhave Univ, Adv Sci & Technol Res Ctr, Hazaribagh 825301, India
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- Singh, Puneet Kumar (author)
- KIIT Univ, Sch Biotechnol, Bhubaneswar 751024, India
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- Nandi, Aditya (author)
- KIIT Univ, Sch Biotechnol, Bhubaneswar 751024, India
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- Mallick, M. A. (author)
- Vinoba Bhave Univ, Adv Sci & Technol Res Ctr, Hazaribagh 825301, India;Vinoba Bhave Univ, Univ Dept Biotechnol, Hazaribagh 825301, India
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- Das, Biswadeep (author)
- KIIT Univ, Sch Biotechnol, Bhubaneswar 751024, India
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- Suar, Mrutyunjay (author)
- KIIT Univ, Sch Biotechnol, Bhubaneswar 751024, India
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- Verma, Suresh K. (author)
- KIIT Univ, Sch Biotechnol, Bhubaneswar 751024, India;Vinoba Bhave Univ, Adv Sci & Technol Res Ctr, Hazaribagh 825301, India
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(creator_code:org_t)
- ACADEMIC PRESS INC ELSEVIER SCIENCE, 2020
- 2020
- English.
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In: Ecotoxicology and Environmental Safety. - : ACADEMIC PRESS INC ELSEVIER SCIENCE. - 0147-6513 .- 1090-2414. ; 192
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Day to day consumption of black pepper raise concern about the detailed information about their medicinal, pharmaceutical values and knowledge about the biocompatibility with respect to ecosystem. This study investigates the in vivo selective molecular biocompatibility of its seed cover (SC) and seed core (SP) powder extract using embryonic zebrafish model. Gas chromatography mass spectrometry (GCMS) analysis of the extract prepared by grinding showed presence of different components with "piperine" as principle component. Biocompatibility analysis showed dose and time dependent selective effect of SC and SP with LC50 of 30.4 mu g/ml and 35.6 mu g/ml, respectively on survivability, hatching and heartbeat rate in embryonic zebrafish. Mechanistic investigation elucidated it as effect of accumulation and internalization of black pepper leading to their influence on structure and function of cellular proteins hatching enzyme (he1a), superoxide dismutase (sod1) and tumor protein (tp53) responsible for delayed hatching, oxidative stress induction and apoptosis. The study provided insight to selective biocompatibility of black pepper expedient to produce higher quality spices with respect to pharmaceutical, clinical and environmental aspects.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Keyword
- Black pepper
- Zebrafish
- Biocompatibility
- Piperine
- Oxidative stress
- Apoptosis
Publication and Content Type
- ref (subject category)
- art (subject category)
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