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Clinical Implicatio...
Clinical Implications of Estimating Glomerular Filtration Rate with Three Different Equations among Older People. Preliminary Results of the Project "Screening for Chronic Kidney Disease among Older People across Europe (SCOPE)"
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- Corsonello, Andrea (author)
- Karolinska Institutet
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- Roller-Wirnsberger, Regina (author)
- Med Univ Graz, Dept Internal Med, A-8036 Graz, Austria
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- Wirnsberger, Gerhard (author)
- Med Univ Graz, Dept Internal Med, A-8036 Graz, Austria
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- Ärnlöv, Johan (author)
- Högskolan Dalarna,Karolinska Institutet,Uppsala universitet,Molekylär epidemiologi,Dalarna Univ, Sch Hlth & Social Studies, S-79131 Falun, Sweden;Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Family Med & Primary Care, S-14152 Huddinge, Sweden,Medicinsk vetenskap,Uppsala University; Karolinska Institutet
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- Carlsson, Axel C (author)
- Uppsala universitet,Molekylär epidemiologi,Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Family Med & Primary Care, S-14152 Huddinge, Sweden
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- Tap, Lisanne (author)
- Erasmus MC, Univ Med Ctr Rotterdam, Dept Internal Med, Sect Geriatr Med, NL-3015 GD Rotterdam, Netherlands
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- Mattace-Raso, Francesco (author)
- Erasmus MC, Univ Med Ctr Rotterdam, Dept Internal Med, Sect Geriatr Med, NL-3015 GD Rotterdam, Netherlands
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- Formiga, Francesc (author)
- Bellvitge Univ Hosp, IDIBELL, Internal Med Dept, Geriatr Unit, Barcelona 08907, Spain
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- Moreno-Gonzalez, Rafael (author)
- Bellvitge Univ Hosp, IDIBELL, Internal Med Dept, Geriatr Unit, Barcelona 08907, Spain
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- Weingart, Christian (author)
- Friedrich Alexander Univ Erlangen Nurnberg, Krankenhaus Barmherzige Bruder, Inst Biomed Aging, Dept Gen Internal Med & Geriatr, D-93049 Regensburg, Germany
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- Sieber, Cornel (author)
- Friedrich Alexander Univ Erlangen Nurnberg, IBA, Dept Internal Med Geriatr, Koberger Str 60, D-90408 Nurnberg, Germany
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- Kostka, Tomasz (author)
- Med Univ Lodz, Hlth Ageing Res Ctr, Dept Geriatr, PL-90647 Lodz, Poland
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- Guligowska, Agnieszka (author)
- Med Univ Lodz, Hlth Ageing Res Ctr, Dept Geriatr, PL-90647 Lodz, Poland
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- Gil, Pedro (author)
- Hosp Clin San Carlos, Dept Geriatr Med, Madrid 28040, Spain
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- Lainez Martinez, Sara (author)
- Hosp Clin San Carlos, Dept Geriatr Med, Madrid 28040, Spain
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- Artzi-Medvedik, Rada (author)
- Ben Gurion Univ Negev, Fac Hlth Sci, Recanati Sch Community Hlth Profess, IL-84105 Beer Sheva, Israel
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- Melzer, Itshak (author)
- Ben Gurion Univ Negev, Fac Hlth Sci, Recanati Sch Community Hlth Profess, IL-84105 Beer Sheva, Israel
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- Lattanzio, Fabrizia (author)
- INRCA Ancona, IRCCS, I-60124 Ancona, Italy
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(creator_code:org_t)
- 2020-01-21
- 2020
- English.
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In: Journal of Clinical Medicine. - : MDPI. - 2077-0383. ; 9:2
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Abstract
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- We aimed at investigating to what extent CKD may be staged interchangeably by three different eGFR equations in older people, and evaluating the source of discrepancies among equations in a population of 2257 patients older than 75 years enrolled in a multicenter observational study. eGFR was calculated by CKD-EPI, BIS and FAS equations. Statistical analysis was carried out by Bland-Altman analysis. kappa statistic was used to quantify the agreement between equations in classifying CKD stages. The impact of selected variables on the difference among equations was graphically explored. The average difference between BIS and FAS was -0.24 (95% limits of agreement (95%LA = -4.64-4.14) mL/min/1.73 m(2). The difference between CKD-EPI and BIS and between CKD-EPI and FAS was 8.97 (95%LA = -2.90-20.84) and 8.72 (95%LA = -2.11-19.56) mL/min/1.73 m(2), respectively. As regards CKD stage classification, kappa value was 0.47 for both CKD-EPI vs. FAS and CKD-EPI vs. BIS, while BIS and FAS had similar classificatory properties (kappa = 0.90). Muscle mass was found related to the difference between CKD-EPI and BIS (R-2 = 0.11) or FAS (R-2 = 0.14), but not to the difference between BIS and FAS. In conclusion, CKD-EPI and BIS/FAS equations are not interchangeable to assess eGFR among older people. Muscle mass may represent a relevant source of discrepancy among eGFR equations.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- chronic kidney disease (CKD)
- Berlin Initiative Study (BIS)
- Full Age Spectrum (FAS)
- estimated glomerular filtration rate (eGFR)
- older patients
- sarcopenia
- muscle mass
- sex
- Health and Welfare
Publication and Content Type
- ref (subject category)
- art (subject category)
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Corsonello, Andr ...
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Roller-Wirnsberg ...
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Wirnsberger, Ger ...
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Ärnlöv, Johan
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Carlsson, Axel C
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Tap, Lisanne
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Mattace-Raso, Fr ...
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Formiga, Frances ...
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Moreno-Gonzalez, ...
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Weingart, Christ ...
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Sieber, Cornel
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Kostka, Tomasz
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Guligowska, Agni ...
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Gil, Pedro
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Lainez Martinez, ...
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Artzi-Medvedik, ...
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Melzer, Itshak
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Lattanzio, Fabri ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Journal of Clini ...
- By the university
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Uppsala University
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Karolinska Institutet
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Högskolan Dalarna