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Recent Advances in ...
Recent Advances in Understanding Biological GTP Hydrolysis through Molecular Simulation
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- Calixto, Ana Rita (author)
- Uppsala universitet,Biokemi
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- Moreira, Catia (author)
- Uppsala universitet,Biokemi,Uppsala Univ, Dept Chem BMC, S-75123 Uppsala, Sweden.
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- Kamerlin, Shina Caroline Lynn, 1981- (author)
- Uppsala universitet,Biokemi
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(creator_code:org_t)
- 2020-02-28
- 2020
- English.
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In: ACS Omega. - : American Chemical Society (ACS). - 2470-1343. ; 5:9, s. 4380-4385
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Abstract
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- GTP hydrolysis is central to biology, being involved in regulating a wide range of cellular processes. However, the mechanisms by which GTPases hydrolyze this critical reaction remain controversial, with multiple mechanistic possibilities having been proposed based on analysis of experimental and computational data. In this mini-review, we discuss advances in our understanding of biological GTP hydrolysis based on recent computational studies and argue in favor of solvent-assisted hydrolysis as a conserved mechanism among GTPases. A concrete understanding of the fundamental mechanisms by which these enzymes facilitate GTP hydrolysis will have significant impact both for drug discovery efforts and for unraveling the role of oncogenic mutations.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
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