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Advances in dual fu...
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Afewerki, SamsonHarvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Engn Med, Cambridge, MA 02139 USA.;MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA.
(author)
Advances in dual functional antimicrobial and osteoinductive biomaterials for orthopaedic applications
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Publisher, publication year, extent ...
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Elsevier BV,2020
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Numbers
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LIBRIS-ID:oai:DiVA.org:uu-409691
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-409691URI
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https://doi.org/10.1016/j.nano.2019.102143DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:for swepub-publicationtype
Notes
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A vast growing problem in orthopaedic medicine is the increase of clinical cases with antibiotic resistant pathogenic microbes, which is predicted to cause higher mortality than all cancers combined by 2050. Bone infectious diseases limit the healing ability of tissues and increase the risk of future injuries due to pathologic tissue remodelling. The traditional treatment for bone infections has several drawbacks and limitations, such as lengthy antibiotic treatment, extensive surgical interventions, and removal of orthopaedic implants and/or prosthesis, all of these resulting in long-term rehabilitation. This is a huge burden to the public health system resulting in increased healthcare costs. Current technologies e.g. co-delivery systems, where antibacterial and osteoinductive agents are delivered encounter challenges such as site-specific delivery, sustained and prolonged release, and biocompatibility. In this review, these aspects are highlighted to promote the invention of the next generation biomaterials to prevent and/or treat bone infections and promote tissue regeneration.
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Bassous, NicoleNortheastern Univ, Dept Chem Engn, Nanomed Lab, Boston, MA 02115 USA.
(author)
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Harb, SamarahSao Paulo State Univ, Inst Chem, Araraquara, SP, Brazil.
(author)
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Palo-Nieto, CarlosUppsala universitet,Institutionen för läkemedelskemi(Swepub:uu)carpa373
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Ruiz-Esparza, Guillermo U.Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Engn Med, Cambridge, MA 02139 USA.;MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA.
(author)
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Marciano, Fernanda R.UFPI Fed Univ Piaui, Dept Phys, Teresina, PI, Brazil.
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Webster, Thomas J.Northeastern Univ, Dept Chem Engn, Nanomed Lab, Boston, MA 02115 USA.
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Aguiar Furtado, Andre SalesUFPI Fed Univ Piaui, Dept Mat Engn, LIMAV Interdisciplinary Lab Adv Mat, BR-64049550 Teresina, PI, Brazil.
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Lobo, Anderson O.UFPI Fed Univ Piaui, Dept Mat Engn, LIMAV Interdisciplinary Lab Adv Mat, BR-64049550 Teresina, PI, Brazil.;MIT, Dept Chem, Cambridge, MA 02139 USA.
(author)
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Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Engn Med, Cambridge, MA 02139 USA.;MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA.Northeastern Univ, Dept Chem Engn, Nanomed Lab, Boston, MA 02115 USA.
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In:Nanomedicine: Elsevier BV241549-96341549-9642
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