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House retinal cell behaviour in space and time using light sheet fluorescence microscopy

Prahst, Claudia (author)
Harvard Med Sch, Ctr Vasc Biol Res, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA.;Harvard Med Sch, Dept Pathol, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA.
Ashrafzadeh, Parham (author)
Mead, Thomas (author)
Francis Crick Inst, London, England.;Kings Coll London, Fac Nat & Math Sci, Dept Informat, London, England.
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Figueiredo, Ana (author)
Inst Med Mol, Lisbon, Portugal.
Chang, Karen (author)
Harvard Med Sch, Schepens Eye Res Inst Massachusetts Eye & Ear, Dept Ophthalmol, Boston, MA 02115 USA.
Richardson, Douglas (author)
Harvard Univ, Harvard Ctr Biol Imaging, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA.
Venkaraman, Lakshmi (author)
Uppsala universitet,Vaskulärbiologi,Harvard Med Sch, Ctr Vasc Biol Res, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA.;Harvard Med Sch, Dept Pathol, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA
Richards, Mark (author)
Uppsala universitet,Vaskulärbiologi
Russo, Ana Martins (author)
Inst Med Mol, Lisbon, Portugal.
Harrington, Kyle (author)
Harvard Med Sch, Ctr Vasc Biol Res, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA.;Harvard Med Sch, Dept Pathol, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA.;Univ Idaho, Virtual Technol & Design, Moscow, ID 83843 USA.
Ouarne, Marie (author)
Inst Med Mol, Lisbon, Portugal.
Pena, Andreia (author)
Inst Med Mol, Lisbon, Portugal.
Chen, Dong Feng (author)
Harvard Med Sch, Schepens Eye Res Inst Massachusetts Eye & Ear, Dept Ophthalmol, Boston, MA 02115 USA.
Claesson-Welsh, Lena (author)
Uppsala universitet,Vaskulärbiologi
Cho, Kin-Sang (author)
Harvard Med Sch, Schepens Eye Res Inst Massachusetts Eye & Ear, Dept Ophthalmol, Boston, MA 02115 USA.;Edith Nourse Rogers Mem Vet Hosp, Geriatr Res Educ & Clin Ctr, Off Res & Dev, Bedford, MA USA.
Franco, Claudio A. (author)
Inst Med Mol, Lisbon, Portugal.
Bentley, Katie (author)
Uppsala universitet,Vaskulärbiologi,Harvard Med Sch, Ctr Vasc Biol Res, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA.;Harvard Med Sch, Dept Pathol, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA.;Francis Crick Inst, London, England.;Kings Coll London, Fac Nat & Math Sci, Dept Informat, London, England.;Boston Univ, Biomed Engn Dept, Boston, MA 02215 USA.
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Harvard Med Sch, Ctr Vasc Biol Res, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA;Harvard Med Sch, Dept Pathol, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA. Francis Crick Inst, London, England.;Kings Coll London, Fac Nat & Math Sci, Dept Informat, London, England. (creator_code:org_t)
2020
2020
English.
In: eLIFE. - 2050-084X. ; 9
Related links:
https://doi.org/10.7...
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https://uu.diva-port... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.7...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • As the general population ages, more people are affected by eye diseases, such as retinopathies. It is therefore critical to improve imaging of eye disease mouse models. Here, we demonstrate that 1) rapid, quantitative 3D and 4D (time lapse) imaging of cellular and subcellular processes in the mouse eye is feasible, with and without tissue clearing, using light-sheet fluorescent microscopy (LSFM); 2) flat-mounting retinas for confocal microscopy significantly distorts tissue morphology, confirmed by quantitative correlative LSFM-Confocal imaging of vessels; 3) LSFM readily reveals new features of even well-studied eye disease mouse models, such as the oxygen-induced retinopathy (OIR) model, including a previously unappreciated 'knotted' morphology to pathological vascular tufts, abnormal cell motility and altered filopodia dynamics when live-imaged. We conclude that quantitative 3D/4D LSFM imaging and analysis has the potential to advance our understanding of the eye, in particular pathological, neurovascular, degenerative processes.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

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