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Cerebral Blood Flow...
Cerebral Blood Flow Measurement in Healthy Children and Children Suffering Severe Traumatic Brain Injury : What Do We Know?
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- Rostami, Elham, 1979- (author)
- Karolinska Institutet,Uppsala universitet,Enblad: Neurokirurgi,Karolinska Inst, Dept Neurosci, Stockholm, Sweden
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- Nilsson, Pelle (author)
- Uppsala universitet,Enblad: Neurokirurgi
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- Enblad, Per (author)
- Uppsala universitet,Enblad: Neurokirurgi
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(creator_code:org_t)
- 2020-04-16
- 2020
- English.
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In: Frontiers in Neurology. - : Frontiers Media SA. - 1664-2295. ; 11
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Abstract
Subject headings
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- Traumatic brain injury is the leading cause of death in children. Children with severe TBI are in need of neurointensive care where the goal is to prevent secondary brain injury by avoiding secondary insults. Monitoring of cerebral blood flow (CBF) and autoregulation in the injured brain is crucial. However, there are limited studies performed in children to investigate this. Current studies report on age dependent increase in CBF with narrow age range. Low initial CBF following TBI has been correlated to poor outcome and may be more prevalent than hyperemia as previously suggested. Impaired cerebral pressure autoregulation is also detected and correlated with poor outcome but it remains to be elucidated if there is a causal relationship. Current studies are few and mainly based on small number of patients between the age of 0-18 years. Considering the changes of CBF and cerebral pressure autoregulation with increasing age, larger studies with more narrow age ranges and multimodality monitoring are required in order to generate data that can optimize the therapy and clinical management of children suffering TBI.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- pediatric brain injury
- cerebral blood flow
- cerebral autoregulation
- traumatic brain injury
- Xenon-CT
- TCD
- head injury children
Publication and Content Type
- ref (subject category)
- for (subject category)
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