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Low-Dose Image-Guid...
Low-Dose Image-Guided Pediatric CNS Radiation Therapy : Final Analysis From a Prospective Low-Dose Cone-Beam CT Protocol From a Multinational Pediatrics Consortium
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- Alcorn, Sara R. (author)
- Johns Hopkins Univ Hosp, Baltimore, MD 21287 USA.
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- Zhou, Xian Chiong (author)
- Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA.
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- Bojechko, Casey (author)
- Univ Washington, Seattle, WA 98195 USA.
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- Rubo, Rodrigo A. (author)
- Ctr Infantil Boldrini, Sao Paulo, Brazil.;Ctr Infantil Boldrini, Regiao, Brazil.
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- Chen, Michael J. (author)
- Grp Apoio Ao Adolescente & Crianca Com Canc, Sao Paulo, Brazil.
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- Dieckmann, Karin (author)
- Univ Klin Strahlentherapie & Strahlenbiol, Vienna, Austria.
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- Ermoian, Ralph P. (author)
- Univ Washington, Seattle, WA 98195 USA.
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- Ford, Eric C. (author)
- Univ Washington, Seattle, WA 98195 USA.
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- Kobyzeva, Daria (author)
- Fed Sci Clin Ctr Childrens Hematol Oncol & Immuno, Moscow, Russia.
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- MacDonald, Shannon M. (author)
- Massachusetts Gen Hosp, Boston, MA 02114 USA.
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- McNutt, Todd R. (author)
- Johns Hopkins Univ Hosp, Baltimore, MD 21287 USA.
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- Nechesnyuk, Alexey (author)
- Fed Sci Clin Ctr Childrens Hematol Oncol & Immuno, Moscow, Russia.
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- Nilsson, Kristina, 1967- (author)
- Uppsala universitet,Experimentell och klinisk onkologi
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- Sjöstrand, Håkan (author)
- Uppsala Univ Hosp, Uppsala, Sweden.
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- Smith, Koren S. (author)
- Johns Hopkins Univ Hosp, Baltimore, MD 21287 USA.
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- Stock, Markus (author)
- Univ Klin Strahlentherapie & Strahlenbiol, Vienna, Austria.
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- Tryggestad, Erik J. (author)
- Mayo Clin, Rochester, MN USA.
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- Villar, Rosangela C. (author)
- Ctr Infantil Boldrini, Sao Paulo, Brazil.;Ctr Infantil Boldrini, Regiao, Brazil.
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- Winey, Brian A. (author)
- Massachusetts Gen Hosp, Boston, MA 02114 USA.
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- Terezakis, Stephanie A. (author)
- Univ Minnesota, Dept Radiat Oncol & Mol Radiat Sci, 420 Delaware St, Minneapolis, MN 55455 USA.
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Johns Hopkins Univ Hosp, Baltimore, MD 21287 USA Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA. (creator_code:org_t)
- 2020-04-24
- 2020
- English.
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In: Technology in Cancer Research & Treatment. - : SAGE PUBLICATIONS INC. - 1533-0346 .- 1533-0338. ; 19
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Abstract
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- Background: Lower-dose cone-beam computed tomography protocols for image-guided radiotherapy may permit target localization while minimizing radiation exposure. We prospectively evaluated a lower-dose cone-beam protocol for central nervous system image-guided radiotherapy across a multinational pediatrics consortium.Methods: Seven institutions prospectively employed a lower-dose cone-beam computed tomography central nervous system protocol (weighted average dose 0.7 mGy) for patients <= 21 years. Treatment table shifts between setup with surface lasers versus cone-beam computed tomography were used to approximate setup accuracy, and vector magnitudes for these shifts were calculated. Setup group mean, interpatient, interinstitution, and random error were estimated, and clinical factors were compared by mixed linear modeling.Results: Among 96 patients, with 2179 pretreatment cone-beam computed tomography acquisitions, median age was 9 years (1-20). Setup parameters were 3.13, 3.02, 1.64, and 1.48 mm for vector magnitude group mean, interpatient, interinstitution, and random error, respectively. On multivariable analysis, there were no significant differences in mean vector magnitude by age, gender, performance status, target location, extent of resection, chemotherapy, or steroid or anesthesia use. Providers rated >99% of images as adequate or better for target localization.Conclusions: A lower-dose cone-beam computed tomography protocol demonstrated table shift vector magnitude that approximate clinical target volume/planning target volume expansions used in central nervous system radiotherapy. There were no significant clinical predictors of setup accuracy identified, supporting use of this lower-dose cone-beam computed tomography protocol across a diverse pediatric population with brain tumors.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- radiotherapy
- image-guided
- IGRT
- brain neoplasms
- prospective study
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Alcorn, Sara R.
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Zhou, Xian Chion ...
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Bojechko, Casey
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Rubo, Rodrigo A.
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Chen, Michael J.
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Dieckmann, Karin
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show more...
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Ermoian, Ralph P ...
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Ford, Eric C.
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Kobyzeva, Daria
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MacDonald, Shann ...
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McNutt, Todd R.
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Nechesnyuk, Alex ...
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Nilsson, Kristin ...
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Sjöstrand, Håkan
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Smith, Koren S.
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Stock, Markus
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Tryggestad, Erik ...
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Villar, Rosangel ...
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Winey, Brian A.
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Terezakis, Steph ...
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- MEDICAL AND HEALTH SCIENCES
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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Technology in Ca ...
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Uppsala University