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The Level Of Myeloi...
The Level Of Myeloid Derived-Suppressor Cells In Peripheral Blood Of Patients With Prostate Cancer After Various Types Of Therapy
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- Sieminska, Izabela (author)
- Jagiellonian Univ, Fac Med, Inst Pediat, Dept Clin Immunol,Med Coll, Wielicka 265, PL-30663 Krakow, Poland.
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- Rychlicka, Edyta (author)
- Uppsala universitet,Medicinsk genetik och genomik
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- Jaszczynski, Janusz (author)
- Natl Res Inst Oncol, Dept Surg, Krakow Branch, Krakow, Poland.
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- Palaczynski, Mikolaj (author)
- Natl Res Inst Oncol, Dept Surg, Krakow Branch, Krakow, Poland.
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- Bukowska-Strakova, Karolina (author)
- Jagiellonian Univ, Fac Med, Inst Pediat, Dept Clin Immunol,Med Coll, Wielicka 265, PL-30663 Krakow, Poland.
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- Ras, Janusz (author)
- Natl Res Inst Oncol, Dept Pathol, Krakow Branch, Krakow, Poland.
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- Dumanski, Jan P. (author)
- Uppsala universitet,Medicinsk genetik och genomik
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- Siedlar, Maciej (author)
- Jagiellonian Univ, Fac Med, Inst Pediat, Dept Clin Immunol,Med Coll, Wielicka 265, PL-30663 Krakow, Poland.
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- Baran, Jaroslaw (author)
- Jagiellonian Univ, Fac Med, Inst Pediat, Dept Clin Immunol,Med Coll, Wielicka 265, PL-30663 Krakow, Poland.
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Jagiellonian Univ, Fac Med, Inst Pediat, Dept Clin Immunol,Med Coll, Wielicka 265, PL-30663 Krakow, Poland Medicinsk genetik och genomik (creator_code:org_t)
- 2020
- 2020
- English.
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In: Polish Journal of Pathology. - 1233-9687 .- 2084-9869. ; 71:1, s. 46-54
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Abstract
Subject headings
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- Prostate cancer is one of the most frequent cancers in men. Although several treatment options exist, their clinical effectiveness is still not satisfactory. One the possible reason of such situation might be the presence of myeloid-derived suppressor cells (MDSC) and their pro-turnorigenic activity. MDSC possess irnmunosuppressive ability and in many studies were shown to support tumor development and progression. In this study we addressed the question whether commonly used therapies of prostate cancer affect the level of MDSC populations in the patients' blood. We compared the level of granulocytic (Gr-MDSC), monocytic (Mo-MDSC) and early stage MDSC (eMDSC) in the blood of patients at different clinical stage and different tumor grading scores, who underwent either surgery or hormonal therapy alone or were given a combined treatment, including e.g. radiotherapy. The obtained results showed that the level of Gr-MDSC was significantly lower in all treated patients comparing to untreated group. On the other hand, surgery or hormonal therapy alone did not affect the level of Mo-MDSC. These results were independent of the PSA level, the tumor grading and clinical stage of the patients. In conclusion, we suggest that Mo-MDSC should be considered as a potential therapy target in the course of prostate cancer treatment to enhance its anti-tumor effectiveness.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- prostate cancer (PC)
- myeloid-derived suppressor cells (MDSC)
- flow cytometry
- prostate specific antigen (PSA)
Publication and Content Type
- ref (subject category)
- art (subject category)
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