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Increased iron abso...
Increased iron absorption in patients with chronic heart failure and iron deficiency
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- Cabrera, Carin C. (author)
- Karolinska Institutet
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- Ekstrom, Mattias (author)
- Karolinska Institutet
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- Linde, Cecilia (author)
- Karolinska Institutet
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- Persson, Hans (author)
- Karolinska Institutet
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- Hage, Camilla (author)
- Karolinska Institutet
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- Eriksson, Maria J. (author)
- Karolinska Institutet
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- Wallen, Hakan (author)
- Karolinska Institutet
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- Persson, Bengt (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Beräkningsbiologi och bioinformatik
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- Tornvall, Per (author)
- Karolinska Institutet
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- Lynga, Patrik (author)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- English.
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In: Journal of Cardiac Failure. - : Elsevier BV. - 1071-9164 .- 1532-8414. ; 26:5, s. 440-443
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Abstract
Subject headings
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- Background: Iron deficiency (ID) is common in patients with chronic heart failure (CHF), but the underlying causes are not fully understood. We investigated whether ID is associated with decreased iron absorption in patients with CHF.Methods and Results: We performed an oral iron-absorption test in 30 patients and 12 controls. The patients had CHF with reduced (n = 15) or preserved (n = 15) ejection fraction and ID, defined as s- ferritin < 100 mu g/L, or s-ferritin 100-299 mu g/L and transferrin saturation < 20%. The controls had no HF or ID and were of similar age and gender. Blood samples were taken before and 2 hours after ingestion of 100 mg ferroglycin sulphate. The primary endpoint was the delta plasma iron at 2 hours. The delta plasma iron was higher in the group with HF than in the control group (median increase 83.8 [61.5;128.5] mu g/dL in HF vs 47.5 [ 30.7;61.5] mu g/dL in controls, P = 0.001), indicating increased iron absorption. There was no significant difference between the groups with preserved or reduced ejection fraction (P = 0.46).Conclusion: We found increased iron absorption in patients with CHF and ID compared to controls without ID and HF, indicating that reduced iron absorption is not a primary cause of the high prevalence of ID in patients with CHF.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Iron deficiency
- heart failure
- iron absorption
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Cabrera, Carin C ...
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Ekstrom, Mattias
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Linde, Cecilia
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Persson, Hans
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Hage, Camilla
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Eriksson, Maria ...
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show more...
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Wallen, Hakan
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Persson, Bengt
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Tornvall, Per
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Lynga, Patrik
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Journal of Cardi ...
- By the university
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Uppsala University
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Karolinska Institutet