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  • Condoluci, AdalgisaUniv Svizzera Italiana, Oncol Res Inst, Bellinzona, Switzerland.;Oncol Inst Southern Switzerland, Bellinzona, Switzerland. (author)

International prognostic score for asymptomatic early-stage chronic lymphocytic leukemia

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • American Society of Hematology,2020
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-414949
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-414949URI
  • https://doi.org/10.1182/blood.2019003453DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:143802909URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Most patients with chronic lymphocytic leukemia (CLL) are diagnosed with early-stage disease and managed with active surveillance. The individual course of patients with early-stage CLL is heterogeneous, and their probability of needing treatment is hardly anticipated at diagnosis. We aimed at developing an international prognostic score to predict time to first treatment (TTFT) in patients with CLL with early, asymptomatic disease (International Prognostic Score for Early-stage CLL [IPS-E]). Individual patient data from 11 international cohorts of patients with early-stage CLL (n = 4933) were analyzed to build and validate the prognostic score. Three covariates were consistently and independently correlated with TTFT: unmutated immunoglobulin heavy variable gene (IGHV), absolute lymphocyte count higher than 15 x 10(9)/L, and presence of palpable lymph nodes. The IPS-E was the sum of the covariates (1 point each), and separated low-risk (score 0), intermediate-risk (score 1), and high-risk (score 2-3) patients showing a distinct TTFT. The score accuracy was validated in 9 cohorts staged by the Binet system and 1 cohort staged by the Rai system. The C-index was 0.74 in the training series and 0.70 in the aggregate of validation series. By meta-analysis of the training and validation cohorts, the 5-year cumulative risk for treatment start was 8.4%, 28.4%, and 61.2% among low-risk, intermediate-risk, and high-risk patients, respectively. The IPS-E is a simple and robust prognostic model that predicts the likelihood of treatment requirement in patients with early-stage CLL. The IPS-E can be useful in clinical management and in the design of early intervention clinical trials.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • di Bergamo, Lodovico TerziUniv Svizzera Italiana, Oncol Res Inst, Bellinzona, Switzerland. (author)
  • Langerbeins, PetraUniv Cologne, Cologne Bonn & German CLL Study Grp, Ctr Integrated Oncol, Cologne, Germany. (author)
  • Hoechstetter, Manuela A.German CLL Study Grp, Hosp Munich Schwabing, Munich, Germany. (author)
  • Herling, Carmen D.Univ Cologne, Cologne Bonn & German CLL Study Grp, Ctr Integrated Oncol, Cologne, Germany. (author)
  • De Paoli, LorenzoUniv Piemonte Orientale, Dept Translat Med, Div Hematol, Novara, Italy. (author)
  • Delgado, JulioHosp Clin Barcelona, Barcelona, Spain. (author)
  • Rabe, Kari G.Mayo Clin, Rochester, MN USA. (author)
  • Gentile, MassimoAzienda Osped Cosenza, Cosenza, Italy. (author)
  • Doubek, MichaelMasaryk Univ, Interni Hematol & Onkol Klin IHOK, Univ Hosp Brno, Brno, Czech Republic.;Masaryk Univ, Fac Med, Brno, Czech Republic.;Masaryk Univ, Cent European Inst Technol, Brno, Czech Republic. (author)
  • Mauro, Francesca R.Karolinska Institutet (author)
  • Chiodin, GiorgiaUniv Southampton, Canc Sci Div, Southampton, Hants, England. (author)
  • Mattsson, MattiasUppsala universitet,Experimentell och klinisk onkologi(Swepub:uu)matma431 (author)
  • Bahlo, JasminUniv Cologne, Cologne Bonn & German CLL Study Grp, Ctr Integrated Oncol, Cologne, Germany. (author)
  • Cutrona, GiovannaIRCCS Osped Policlin San Martino, Genoa, Italy. (author)
  • Kotaskova, JanaMasaryk Univ, Interni Hematol & Onkol Klin IHOK, Univ Hosp Brno, Brno, Czech Republic.;Masaryk Univ, Fac Med, Brno, Czech Republic.;Masaryk Univ, Cent European Inst Technol, Brno, Czech Republic. (author)
  • Deambrogi, ClaraUniv Piemonte Orientale, Dept Translat Med, Div Hematol, Novara, Italy. (author)
  • Smedby, Karin E.Karolinska Institutet (author)
  • Spina, ValeriaUniv Svizzera Italiana, Oncol Res Inst, Bellinzona, Switzerland. (author)
  • Bruscaggin, AlessioUniv Svizzera Italiana, Oncol Res Inst, Bellinzona, Switzerland. (author)
  • Wu, WeiUniv Svizzera Italiana, Oncol Res Inst, Bellinzona, Switzerland.;IRCCS Osped Policlin San Martino, Genoa, Italy. (author)
  • Moia, RiccardoUniv Piemonte Orientale, Dept Translat Med, Div Hematol, Novara, Italy. (author)
  • Bianchi, ElenaOncol Inst Southern Switzerland, Bellinzona, Switzerland. (author)
  • Gerber, BernhardOncol Inst Southern Switzerland, Bellinzona, Switzerland. (author)
  • Zucca, EmanueleOncol Inst Southern Switzerland, Bellinzona, Switzerland. (author)
  • Gillessen, SilkeOncol Inst Southern Switzerland, Bellinzona, Switzerland. (author)
  • Ghielmini, MicheleOncol Inst Southern Switzerland, Bellinzona, Switzerland. (author)
  • Cavalli, FrancoOncol Inst Southern Switzerland, Bellinzona, Switzerland. (author)
  • Stussi, GeorgOncol Inst Southern Switzerland, Bellinzona, Switzerland. (author)
  • Hess, Mark A.Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. (author)
  • Baumann, Tycho S.Hosp Clin Barcelona, Barcelona, Spain. (author)
  • Neri, AntoninoUniv Milan, Dept Oncol & Hematooncol, Milan, Italy. (author)
  • Ferrarini, ManlioUniv Genoa, Dept Expt Med, Genoa, Italy. (author)
  • Rosenquist, RichardKarolinska Inst, Stockholm, Sweden. Nanjing Med Univ, Affiliated Hosp 1, Jiangsu Prov Hosp, Nanjing, Peoples R China. (author)
  • Forconi, FrancescoUniv Southampton, Canc Sci Div, Southampton, Hants, England.;Southampton Univ Hosp Trust, Southampton, Hants, England. (author)
  • Foa, RobinSapienza Univ, Div Hematol, Rome, Italy. (author)
  • Pospisilova, SarkaMasaryk Univ, Interni Hematol & Onkol Klin IHOK, Univ Hosp Brno, Brno, Czech Republic.;Masaryk Univ, Fac Med, Brno, Czech Republic.;Masaryk Univ, Cent European Inst Technol, Brno, Czech Republic. (author)
  • Morabito, FortunatoBiotechnol Res Unit Aprigliano, Cosenza, Italy.;Augusta Victoria Hosp, Jerusalem, Israel. (author)
  • Stilgenbauer, StephanUniv Hosp Ulm, Dept Internal Med 3, Ulm, Germany. (author)
  • Doehner, HartmutUniv Hosp Ulm, Dept Internal Med 3, Ulm, Germany. (author)
  • Parikh, Sameer A.Mayo Clin, Rochester, MN USA. (author)
  • Wierda, William G.Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. (author)
  • Montserrat, EmiliHosp Clin Barcelona, Barcelona, Spain.;Univ Barcelona, Inst Hematol & Oncol, Barcelona, Spain. (author)
  • Gaidano, GianlucaUniv Piemonte Orientale, Dept Translat Med, Div Hematol, Novara, Italy. (author)
  • Hallek, MichaelUniv Cologne, Cologne Bonn & German CLL Study Grp, Ctr Integrated Oncol, Cologne, Germany. (author)
  • Rossi, DavideUniv Svizzera Italiana, Oncol Res Inst, Bellinzona, Switzerland.;Oncol Inst Southern Switzerland, Bellinzona, Switzerland. (author)
  • Univ Svizzera Italiana, Oncol Res Inst, Bellinzona, Switzerland.;Oncol Inst Southern Switzerland, Bellinzona, Switzerland.Univ Svizzera Italiana, Oncol Res Inst, Bellinzona, Switzerland. (creator_code:org_t)

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  • In:Blood: American Society of Hematology135:21, s. 1859-18690006-49711528-0020

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