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Radiation Triggers ...
Radiation Triggers a Dynamic Sequence of Transient Microglial Alterations in Juvenile Brain
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- Osman, Ahmed M. (author)
- Karolinska Institutet
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- Sun, Ying (author)
- Uppsala universitet,Vaskulärbiologi
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- Burns, Terry C. (author)
- Mayo Clin, Dept Neurol Surg, Rochester, MN 55902 USA.
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- He, Liqun (author)
- Uppsala universitet,Vaskulärbiologi
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- Kee, Nigel (author)
- Karolinska Institutet
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- Oliva-Vilarnau, Nuria (author)
- Karolinska Inst, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden.
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- Alevyzaki, Androniki (author)
- Karolinska Inst, Dept Womens & Childrens Hlth, S-17164 Stockholm, Sweden.
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- Zhou, Kai (author)
- Karolinska Inst, Dept Womens & Childrens Hlth, S-17164 Stockholm, Sweden.;Childrens Hosp Zhengzhou, Dept Pediat, Zhengzhou 450018, Peoples R China.
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- Louhivuori, Lauri (author)
- Karolinska Inst, Dept Med Biochem & Biophys, S-17177 Stockholm, Sweden.
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- Uhlen, Per (author)
- Karolinska Institutet
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- Hedlund, Eva (author)
- Karolinska Institutet
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- Betsholtz, Christer (author)
- Uppsala universitet,Vaskulärbiologi,Karolinska Inst, Integrated Cardiometab Ctr, Dept Med, Novum, S-14157 Stockholm, Sweden.
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- Lauschke, Volker M. (author)
- Karolinska Institutet
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- Kele, Julianna (author)
- Karolinska Institutet
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- Blomgren, Klas (author)
- Karolinska Institutet
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(creator_code:org_t)
- CELL PRESS, 2020
- 2020
- English.
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In: Cell Reports. - : CELL PRESS. - 2211-1247. ; 31:9
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Abstract
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- Cranial irradiation (IR), an effective tool to treat malignant brain tumors, triggers a chronic pro-inflammatory microglial response, at least in the adult brain. Using single-cell and bulk RNA sequencing, combined with histology, we show that the microglial response in the juvenile mouse hippocampus is rapid but returns toward normal within 1 week. The response is characterized by a series of temporally distinct homeostasis-, sensome-, and inflammation-related molecular signatures. We find that a single microglial cell simultaneously upregulates transcripts associated with pro- and anti-inflammatory microglial phenotypes. Finally, we show that juvenile and adult irradiated microglia are already transcriptionally distinct in the early phase after IR. Our results indicate that microglia are involved in the initial stages but may not be responsible for driving long-term inflammation in the juvenile brain.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Osman, Ahmed M.
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Sun, Ying
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Burns, Terry C.
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He, Liqun
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Kee, Nigel
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Oliva-Vilarnau, ...
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Alevyzaki, Andro ...
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Zhou, Kai
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Louhivuori, Laur ...
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Uhlen, Per
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Hedlund, Eva
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Betsholtz, Chris ...
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Lauschke, Volker ...
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Kele, Julianna
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Blomgren, Klas
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Cell Reports
- By the university
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Uppsala University
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Karolinska Institutet