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  • Kloosterman, MarielleUniv Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands. (author)

Characteristics and outcomes of atrial fibrillation in patients without traditional risk factors : an RE-LY AF registry analysis

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2020-03-26
  • Oxford University Press (OUP),2020
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-418946
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-418946URI
  • https://doi.org/10.1093/europace/euz360DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Aims: Data on patient characteristics, prevalence, and outcomes of atrial fibrillation (AF) patients without traditional risk factors, often labelled 'lone AF', are sparse. Methods and results: The RE-LY AF registry included 15 400 individuals who presented to emergency departments with AF in 47 countries. This analysis focused on patients without traditional risk factors, including age >= 60years, hypertension, coronary artery disease, heart failure, left ventricular hypertrophy, congenital heart disease, pulmonary disease, valve heart disease, hyperthyroidism, and prior cardiac surgery. Patients without traditional risk factors were compared with age- and region-matched controls with traditional risk factors (1:3 fashion). In 796 (5%) patients, no traditional risk factors were present. However, 98% (779/796) had less-established or borderline risk factors, including borderline hypertension (130-140/80-90mmHg; 47%), chronic kidney disease (eGFR<60mL/min; 57%), obesity (body mass index>30; 19%), diabetes (5%), excessive alcohol intake (>14 units/week; 4%), and smoking (25%). Compared with patients with traditional risk factors (n=2388), patients without traditional risk factors were more often men (74% vs. 59%, P<0.001) had paroxysmal AF (55% vs. 37%, P<0.001) and less AF persistence after 1 year (21% vs. 49%, P<0.001). Furthermore, 1-year stroke occurrence rate (0.6% vs. 2.0%, P=0.013) and heart failure hospitalizations (0.9% vs. 12.5%, P<0.001) were lower. However, risk of AF-related re-hospitalization was similar (18% vs. 21%, P=0.09). Conclusion: Almost all patients without traditionally defined AF risk factors have less-established or borderline risk factors. These patients have a favourable 1-year prognosis, but risk of AF-related re-hospitalization remains high. Greater emphasis should be placed on recognition and management of less-established or borderline risk factors.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Oldgren, Jonas,1964-Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)jonaoldg (author)
  • Conen, DavidMcMaster Univ, Populat Hlth Res Inst, Dept Med, 30 Birge St,Room C3-121, Hamilton, ON L8L 0A6, Canada. (author)
  • Wong, Jorge A.McMaster Univ, Populat Hlth Res Inst, Dept Med, 30 Birge St,Room C3-121, Hamilton, ON L8L 0A6, Canada. (author)
  • Connolly, Stuart J.McMaster Univ, Populat Hlth Res Inst, Dept Med, 30 Birge St,Room C3-121, Hamilton, ON L8L 0A6, Canada. (author)
  • Avezum, AlvaroDante Pazzanese Inst Cardiol, Div Cardiol, Sao Paulo, Brazil. (author)
  • Yusuf, SalimMcMaster Univ, Populat Hlth Res Inst, Dept Med, 30 Birge St,Room C3-121, Hamilton, ON L8L 0A6, Canada. (author)
  • Ezekowitz, Michael D.Med Coll & Lankenau Med Ctr, Dept Med, Wynnewood, PA USA. (author)
  • Wallentin, Lars,1943-Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)larswall (author)
  • Ntep-Gweth, MarieHop Cent Yaounde, Dept Med, Yaounde, Cameroon. (author)
  • Joseph, PhilipMcMaster Univ, Populat Hlth Res Inst, Dept Med, 30 Birge St,Room C3-121, Hamilton, ON L8L 0A6, Canada. (author)
  • Barrett, Tyler W.Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN USA. (author)
  • Tanosmsup, SupachaiMahidol Univ, Dept Med, Bangkok, Thailand. (author)
  • McIntyre, William F.McMaster Univ, Populat Hlth Res Inst, Dept Med, 30 Birge St,Room C3-121, Hamilton, ON L8L 0A6, Canada. (author)
  • Lee, Shun FuMcMaster Univ, Populat Hlth Res Inst, Dept Med, 30 Birge St,Room C3-121, Hamilton, ON L8L 0A6, Canada. (author)
  • Parkash, RatikaQueen Elizabeth 2 Hlth Sci Ctr, Dept Med, Halifax, NS, Canada.;Dalhousie Univ, Halifax, NS, Canada. (author)
  • Amit, GuyMcMaster Univ, Populat Hlth Res Inst, Dept Med, 30 Birge St,Room C3-121, Hamilton, ON L8L 0A6, Canada. (author)
  • Grinvalds, AlexMcMaster Univ, Populat Hlth Res Inst, Dept Med, 30 Birge St,Room C3-121, Hamilton, ON L8L 0A6, Canada. (author)
  • Van Gelder, Isabelle C.Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands. (author)
  • Healey, Jeff S.McMaster Univ, Populat Hlth Res Inst, Dept Med, 30 Birge St,Room C3-121, Hamilton, ON L8L 0A6, Canada. (author)
  • Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands.Kardiologi (creator_code:org_t)

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  • In:Europace: Oxford University Press (OUP)22:6, s. 870-8771099-51291532-2092

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