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Characteristics and...
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Kloosterman, MarielleUniv Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands.
(author)
Characteristics and outcomes of atrial fibrillation in patients without traditional risk factors : an RE-LY AF registry analysis
- Article/chapterEnglish2020
Publisher, publication year, extent ...
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2020-03-26
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Oxford University Press (OUP),2020
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-418946
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-418946URI
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https://doi.org/10.1093/europace/euz360DOI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Aims: Data on patient characteristics, prevalence, and outcomes of atrial fibrillation (AF) patients without traditional risk factors, often labelled 'lone AF', are sparse. Methods and results: The RE-LY AF registry included 15 400 individuals who presented to emergency departments with AF in 47 countries. This analysis focused on patients without traditional risk factors, including age >= 60years, hypertension, coronary artery disease, heart failure, left ventricular hypertrophy, congenital heart disease, pulmonary disease, valve heart disease, hyperthyroidism, and prior cardiac surgery. Patients without traditional risk factors were compared with age- and region-matched controls with traditional risk factors (1:3 fashion). In 796 (5%) patients, no traditional risk factors were present. However, 98% (779/796) had less-established or borderline risk factors, including borderline hypertension (130-140/80-90mmHg; 47%), chronic kidney disease (eGFR<60mL/min; 57%), obesity (body mass index>30; 19%), diabetes (5%), excessive alcohol intake (>14 units/week; 4%), and smoking (25%). Compared with patients with traditional risk factors (n=2388), patients without traditional risk factors were more often men (74% vs. 59%, P<0.001) had paroxysmal AF (55% vs. 37%, P<0.001) and less AF persistence after 1 year (21% vs. 49%, P<0.001). Furthermore, 1-year stroke occurrence rate (0.6% vs. 2.0%, P=0.013) and heart failure hospitalizations (0.9% vs. 12.5%, P<0.001) were lower. However, risk of AF-related re-hospitalization was similar (18% vs. 21%, P=0.09). Conclusion: Almost all patients without traditionally defined AF risk factors have less-established or borderline risk factors. These patients have a favourable 1-year prognosis, but risk of AF-related re-hospitalization remains high. Greater emphasis should be placed on recognition and management of less-established or borderline risk factors.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Oldgren, Jonas,1964-Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)jonaoldg
(author)
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Conen, DavidMcMaster Univ, Populat Hlth Res Inst, Dept Med, 30 Birge St,Room C3-121, Hamilton, ON L8L 0A6, Canada.
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Wong, Jorge A.McMaster Univ, Populat Hlth Res Inst, Dept Med, 30 Birge St,Room C3-121, Hamilton, ON L8L 0A6, Canada.
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Connolly, Stuart J.McMaster Univ, Populat Hlth Res Inst, Dept Med, 30 Birge St,Room C3-121, Hamilton, ON L8L 0A6, Canada.
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Avezum, AlvaroDante Pazzanese Inst Cardiol, Div Cardiol, Sao Paulo, Brazil.
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Yusuf, SalimMcMaster Univ, Populat Hlth Res Inst, Dept Med, 30 Birge St,Room C3-121, Hamilton, ON L8L 0A6, Canada.
(author)
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Ezekowitz, Michael D.Med Coll & Lankenau Med Ctr, Dept Med, Wynnewood, PA USA.
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Wallentin, Lars,1943-Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)larswall
(author)
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Ntep-Gweth, MarieHop Cent Yaounde, Dept Med, Yaounde, Cameroon.
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Joseph, PhilipMcMaster Univ, Populat Hlth Res Inst, Dept Med, 30 Birge St,Room C3-121, Hamilton, ON L8L 0A6, Canada.
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Barrett, Tyler W.Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN USA.
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Tanosmsup, SupachaiMahidol Univ, Dept Med, Bangkok, Thailand.
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McIntyre, William F.McMaster Univ, Populat Hlth Res Inst, Dept Med, 30 Birge St,Room C3-121, Hamilton, ON L8L 0A6, Canada.
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Lee, Shun FuMcMaster Univ, Populat Hlth Res Inst, Dept Med, 30 Birge St,Room C3-121, Hamilton, ON L8L 0A6, Canada.
(author)
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Parkash, RatikaQueen Elizabeth 2 Hlth Sci Ctr, Dept Med, Halifax, NS, Canada.;Dalhousie Univ, Halifax, NS, Canada.
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Amit, GuyMcMaster Univ, Populat Hlth Res Inst, Dept Med, 30 Birge St,Room C3-121, Hamilton, ON L8L 0A6, Canada.
(author)
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Grinvalds, AlexMcMaster Univ, Populat Hlth Res Inst, Dept Med, 30 Birge St,Room C3-121, Hamilton, ON L8L 0A6, Canada.
(author)
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Van Gelder, Isabelle C.Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands.
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Healey, Jeff S.McMaster Univ, Populat Hlth Res Inst, Dept Med, 30 Birge St,Room C3-121, Hamilton, ON L8L 0A6, Canada.
(author)
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Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands.Kardiologi
(creator_code:org_t)
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In:Europace: Oxford University Press (OUP)22:6, s. 870-8771099-51291532-2092
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