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Specific fibroblast...
Specific fibroblast subpopulations and neuronal structures provide local sources of Vegfc-processing components during zebrafish lymphangiogenesis
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- Wang, Guangxia (author)
- WWU Munster, Inst Cardiovasc Organogenesis & Regenerat, Munster, Germany.;WWU Munster, Fac Med, Munster, Germany.;WWU Munster, Cells Mot Cluster Excellence, Munster, Germany.
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- Muhl, Lars (author)
- Karolinska Institutet
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- Padberg, Yvonne (author)
- WWU Munster, Inst Cardiovasc Organogenesis & Regenerat, Munster, Germany.;WWU Munster, Fac Med, Munster, Germany.;WWU Munster, Cells Mot Cluster Excellence, Munster, Germany.
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- Dupont, Laura (author)
- Univ Liege, Lab Connect Tissue Biol, GIGA, Liege, Belgium.
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- Peterson-Maduro, Josi (author)
- Hubrecht Inst KNAW, Utrecht, Netherlands.;UMC Utrecht, Utrecht, Netherlands.
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- Stehling, Martin (author)
- Max Planck Inst Mol Biomed, Flow Cytometry Unit, Munster, Germany.
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- le Noble, Ferdinand (author)
- Karlsruhe Inst Technol KIT, Zool Inst, Dept Cell & Dev Biol, Karlsruhe, Germany.;Karlsruhe Inst Technol KIT, Inst Biol & Chem Syst, Karlsruhe, Germany.;Heidelberg Univ, Inst Expt Cardiol, Heidelberg, Germany.;DZHK German Ctr Cardiovasc Res, Partner Site, Heidelberg, Germany.
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- Colige, Alain (author)
- Univ Liege, Lab Connect Tissue Biol, GIGA, Liege, Belgium.
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- Betsholtz, Christer (author)
- Uppsala universitet,Vaskulärbiologi,Karolinska Inst, Integrated Cardio Metab Ctr, Dept Med, Huddinge, Sweden
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- Schulte-Merker, Stefan (author)
- WWU Munster, Inst Cardiovasc Organogenesis & Regenerat, Munster, Germany.;WWU Munster, Fac Med, Munster, Germany.;WWU Munster, Cells Mot Cluster Excellence, Munster, Germany.
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- van Impel, Andreas (author)
- WWU Munster, Inst Cardiovasc Organogenesis & Regenerat, Munster, Germany.;WWU Munster, Fac Med, Munster, Germany.;WWU Munster, Cells Mot Cluster Excellence, Munster, Germany.
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Karolinska Institutet WWU Munster, Inst Cardiovasc Organogenesis & Regenerat, Munster, Germany;WWU Munster, Fac Med, Munster, Germany.;WWU Munster, Cells Mot Cluster Excellence, Munster, Germany. (creator_code:org_t)
- 2020-06-01
- 2020
- English.
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1
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Abstract
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- Proteolytical processing of the growth factor VEGFC through the concerted activity of CCBE1 and ADAMTS3 is required for lymphatic development to occur. How these factors act together in time and space, and which cell types produce these factors is not understood. Here we assess the function of Adamts3 and the related protease Adamts14 during zebrafish lymphangiogenesis and show both proteins to be able to process Vegfc. Only the simultaneous loss of both protein functions results in lymphatic defects identical to vegfc loss-of-function situations. Cell transplantation experiments demonstrate neuronal structures and/or fibroblasts to constitute cellular sources not only for both proteases but also for Ccbe1 and Vegfc. We further show that this locally restricted Vegfc maturation is needed to trigger normal lymphatic sprouting and directional migration. Our data provide a single-cell resolution model for establishing secretion and processing hubs for Vegfc during developmental lymphangiogenesis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Wang, Guangxia
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Muhl, Lars
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Padberg, Yvonne
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Dupont, Laura
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Peterson-Maduro, ...
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Stehling, Martin
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le Noble, Ferdin ...
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Colige, Alain
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Betsholtz, Chris ...
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Schulte-Merker, ...
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van Impel, Andre ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Nature Communica ...
- By the university
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Uppsala University
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Karolinska Institutet