Search: onr:"swepub:oai:DiVA.org:uu-418958" >
Specific fibroblast...
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Wang, GuangxiaWWU Munster, Inst Cardiovasc Organogenesis & Regenerat, Munster, Germany.;WWU Munster, Fac Med, Munster, Germany.;WWU Munster, Cells Mot Cluster Excellence, Munster, Germany.
(author)
Specific fibroblast subpopulations and neuronal structures provide local sources of Vegfc-processing components during zebrafish lymphangiogenesis
- Article/chapterEnglish2020
Publisher, publication year, extent ...
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2020-06-01
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Springer Science and Business Media LLC,2020
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-418958
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-418958URI
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https://doi.org/10.1038/s41467-020-16552-7DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:144014781URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Proteolytical processing of the growth factor VEGFC through the concerted activity of CCBE1 and ADAMTS3 is required for lymphatic development to occur. How these factors act together in time and space, and which cell types produce these factors is not understood. Here we assess the function of Adamts3 and the related protease Adamts14 during zebrafish lymphangiogenesis and show both proteins to be able to process Vegfc. Only the simultaneous loss of both protein functions results in lymphatic defects identical to vegfc loss-of-function situations. Cell transplantation experiments demonstrate neuronal structures and/or fibroblasts to constitute cellular sources not only for both proteases but also for Ccbe1 and Vegfc. We further show that this locally restricted Vegfc maturation is needed to trigger normal lymphatic sprouting and directional migration. Our data provide a single-cell resolution model for establishing secretion and processing hubs for Vegfc during developmental lymphangiogenesis.
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Muhl, LarsKarolinska Institutet
(author)
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Padberg, YvonneWWU Munster, Inst Cardiovasc Organogenesis & Regenerat, Munster, Germany.;WWU Munster, Fac Med, Munster, Germany.;WWU Munster, Cells Mot Cluster Excellence, Munster, Germany.
(author)
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Dupont, LauraUniv Liege, Lab Connect Tissue Biol, GIGA, Liege, Belgium.
(author)
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Peterson-Maduro, JosiHubrecht Inst KNAW, Utrecht, Netherlands.;UMC Utrecht, Utrecht, Netherlands.
(author)
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Stehling, MartinMax Planck Inst Mol Biomed, Flow Cytometry Unit, Munster, Germany.
(author)
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le Noble, FerdinandKarlsruhe Inst Technol KIT, Zool Inst, Dept Cell & Dev Biol, Karlsruhe, Germany.;Karlsruhe Inst Technol KIT, Inst Biol & Chem Syst, Karlsruhe, Germany.;Heidelberg Univ, Inst Expt Cardiol, Heidelberg, Germany.;DZHK German Ctr Cardiovasc Res, Partner Site, Heidelberg, Germany.
(author)
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Colige, AlainUniv Liege, Lab Connect Tissue Biol, GIGA, Liege, Belgium.
(author)
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Betsholtz, ChristerUppsala universitet,Vaskulärbiologi,Karolinska Inst, Integrated Cardio Metab Ctr, Dept Med, Huddinge, Sweden(Swepub:uu)chbet517
(author)
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Schulte-Merker, StefanWWU Munster, Inst Cardiovasc Organogenesis & Regenerat, Munster, Germany.;WWU Munster, Fac Med, Munster, Germany.;WWU Munster, Cells Mot Cluster Excellence, Munster, Germany.
(author)
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van Impel, AndreasWWU Munster, Inst Cardiovasc Organogenesis & Regenerat, Munster, Germany.;WWU Munster, Fac Med, Munster, Germany.;WWU Munster, Cells Mot Cluster Excellence, Munster, Germany.
(author)
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Karolinska InstitutetWWU Munster, Inst Cardiovasc Organogenesis & Regenerat, Munster, Germany.;WWU Munster, Fac Med, Munster, Germany.;WWU Munster, Cells Mot Cluster Excellence, Munster, Germany.
(creator_code:org_t)
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In:Nature Communications: Springer Science and Business Media LLC11:12041-1723
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Wang, Guangxia
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Muhl, Lars
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